Nursing Practice Today 2017. 4(3):154-163.

The effect of saffron on sexual dysfunction in women of reproductive age
Maoumeh Rahmati, Fatemeh Rahimikian, Mandana Mirmohammadali, Khadijeh Azimi, Saeid Goodarzi, Abbas Mehran

Abstract


Background & Aim: Sexual dysfunction is a common matter among women which has a significant effect on human’s life. Various methods have been evaluated for encountering and treatment of sexual dysfunction. Considering the effects of saffron and shortage of conducted studies in this field, the aim of the present study was to evaluate the effect of saffron on sexual dysfunction in women of reproductive age.

Methods & Materials: The present clinical trial was conducted on 69 women of 18 to 39 years old who referred to the health centers of the Arak University of Medical Sciences in 2013. Participants were selected using continuous sampling method and were randomly allocated into two groups of intervention and control. The intervention was performed as using saffron extract capsule for 8 weeks and comparing it to consumption of placebo capsules. The status of participants’ sexual performance was evaluated using Female Sexual Function Index before the intervention and four and eight weeks after the start of the intervention. Data were analyzed through SPSS software using chi square test, independent t-test and Cochrane test.

Results: Results showed no significant difference between both groups regarding their sexual dysfunction at the beginning of the study. Comparing the two groups of intervention and control four weeks after the start of the intervention showed a significant difference between their excitement and desire. However, eight weeks after the start of the intervention, the difference between both groups regarding their total sexual dysfunction and all of its aspects except for lubrication and dyspareunia was statistically significant.

Conclusion: Considering the effect of saffron on improvement of women’s sexual performance and also considering the safety of this herbal drug, saffron could be used for improvement of sexual performance in women of reproductive age.


Keywords


women’s sexual performance; Saffron extract; reproductive ages; sexual dysfunction

Full Text:

PDF

References


Puri BK, Treasaden IH. Textbook of psychiatry. Elsevier Health Sciences; 2011.

Andersen BL, Cyranowski JM. Women's sexuality: Behaviors, responses, and individual differences. Journal of Consulting and Clinical Psychology. 1995;63(6):891.

Tahmasebi H, Abasi E. Sexual function and its relation with depression in referring women to health centers affiliated to Medical Science University in Sari Township. Family Health. 2013;1(3):40-4.

WHO. Defining sexual health: report of a technical consultation on sexual health, 28-31 January 2002, Geneva. World Health Organization; 2006.

Shakarami M, DAVARNIA R, Zahrakar K, Gohari S. The effect of sex education on sexual intimacy of married women. Iranian Journal of Psychiatric Nursing. 2014;2(1):34-42.

Hassanzadeh S. The use of Shiatsu in treatment decreased libido of women. The first congress of family and sexual problems; 2005; Shahed University. 2005.

Mirghafourvand M. Mohammad-Alizadeh-Charandabi S, Asghari-Jafarabadi M, Tavananezhad N, Karkhane M. Socio Demographic Predictors of Marital Satisfaction in Women of Reproductive Age, Tabriz IJOGI. 2013;16(72):1-12.

Shahhosseini Z, Gardeshi ZH, Pourasghar M, Salehi F. A review of affecting factors on sexual satisfaction in women. Materia socio-medica. 2014;26(6):378.

WHO. The world health report 2002: reducing risks, promoting healthy life. World Health Organization; 2002.

Rosen RC. Prevalence and risk factors of sexual dysfunction in men and women. Current Psychiatry Reports. 2000;2(3):189-95.

Palacios S, Castaño R, Grazziotin A. Epidemiology of female sexual dysfunction. Maturitas. 2009;63(2):119-23.

Graziottin A, Serafini A, Palacios S. Aetiology, diagnostic algorithms and prognosis of female sexual dysfunction. Maturitas. 2009;63(2):128-34.

Jha S, Thakar R. Female sexual dysfunction. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010;153(2):117-23.

Mimoun S, Wylie K. Female sexual dysfunctions: definitions and classification. Maturitas. 2009;63(2):116-8.

APA. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013.

McCool ME, Zuelke A, Theurich MA, Knuettel H, Ricci C, Apfelbacher C. Prevalence of female sexual dysfunction among premenopausal women: A systematic review and meta-analysis of observational studies. Sexual Medicine Reviews. 2016;4(3):197-212.

Nappi RE, Cucinella L, Martella S, Rossi M, Tiranini L, Martini E. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Maturitas. 2016;94:87-91.

Ibrahim ZM, Ahmed MR, Ahmed WAS. Prevalence and risk factors for female sexual dysfunction among Egyptian women. Archives of gynecology and obstetrics. 2013;287(6):1173-80.

Mishra VV, Nanda S, Vyas B, Aggarwal R, Choudhary S, Saini SR. Prevalence of female sexual dysfunction among Indian fertile females. Journal of Mid-life Health. 2016;7(4):154.

Ranjbaran M, Chizary M, Matory P. Prevalence of female sexual dysfunction in Iran: Systematic review and Meta-analysis. Journal of Sabzevar University of Medical Sciences. 2016;22(7):117-1125.

Mazinani R, Akbari Mehr M, Kaskian A, Kashanian M. Evaluation of Prevalence of sexual dysfunctions and its related factors in women. Razi Journal of Medical Sciences. 2013;19(105):59-66.

HoseiniTabaghdehi M, Hoseini F. The relative frequency of sexual dysfunction and some related factors in the women referred to the health centers of Sari city (2006). Journal of Mazandaran University of Medical Sciences. 2012;22(91):102-7.

Ramezani TF, Farahmand M, Mehrabi Y, Malekafzali H, Abedini M. Prevalence of female sexual dysfunction and its correlated factors: a population based study. Payesh. 2012;11(6):869-75.

Valadan M, Shariat M, Rezaei Z, Hagholahi F, Sheikholeslami G, Bandegi P. A comparative study on quality of life and sexual function after vaginal delivery and Cesarean section. Nursing Practice Today. 2015;1(4):176-82.

Dehkordi AliAkbari M. Examination of relationship between Sexual function among women with Marital adjustment. J Res Behav Sci. 2010;4(3):199-206.

Lipshultz LI, Pastuszak AW, Goldstein AT, Giraldi A, Perelman MA. Management of Sexual Dysfunction in Men and Women: An Interdisciplinary Approach. Springer; 2016.

Tabatabayi A, Sajjadian I, Motamedi M. Effectiveness of Acceptance and Commitment Therapy on Sexual Function, Sexual Self-Consciousness and Sexual Assertiveness among Women with Sexual Dysfunction. J Res Behav Sci. 2017;15(1):84-92.

Goldstein I, Meston CM, Davis S, Traish A. Women's sexual function and dysfunction: study, diagnosis and treatment. CRC Press; 2005.

Pastor Z. Female sexual desire disorders--prevalence, classification and treatment possibilities. Ceska gynekologie/Ceska lekarska spolecnost J Ev Purkyne. 2011;76(1):59-64.

Sexual dysfunction in women: Management [database on the Internet]. UpToDate. 2017 [cited. Available from: https://www.uptodate.com/contents/sexual-dysfunction-in-women-management?source=search_result&search=Female%20sexual%20dysfunction%20management&selectedTitle=1~51.

Sumalatha K, Kumar S, Lakshmi SM. Review on natural aphrodisiac potentials to treat sexual dysfunction. Int J Pharm Ther. 2010;1:10-8.

Sewell RD, Rafieian-Kopaei M. The history and ups and downs of herbal medicine usage. J HerbMed Pharmacol. 2014;3(1):1-3.

Rezai zadeh H. Traditional Medicine Strategy. Tehran: Tehran University of Medical Sciences; 2005.

Licón C, Carmona M, Llorens S, Berruga MI, Alonso GL. Potential healthy effects of saffron spice (Crocus sativus L. stigmas) consumption. Functional Plant Sci Biotechnol. 2010;4:64-73.

Kotta S, Ansari SH, Ali J. Exploring scientifically proven herbal aphrodisiacs. Pharmacognosy reviews. 2013;7(13):1.

Selamoglu Z, Ozgen S. Therapeutic Potential of Saffron Crocus (Crocus sativus L.). Turkish Journal of Agriculture-Food Science and Technology. 2016;4(12):1240-5.

Javadi B, Sahebkar A, Emami SA. A survey on saffron in major Islamic traditional medicine books. Iranian journal of basic medical sciences. 2013;16(1):1-11.

Vahedi M, Govil S, Kumar S, Shrivastava D, Karimi R, S Bisen P. Therapeutic Applications of Crocus sativus L.(Saffron): A Review. The Natural Products Journal. 2016;6(3):162-71.

Mokhber ME, Eimani H, Bigdeli M, Ebrahimi B, Shahverdi A, Golkar NA, et al. A comparative study of saffron aqueous extract and its active ingredient, crocin on the in vitro maturation, in vitro fertilization, and in vitro culture of mouse oocytes. Taiwanese journal of obstetrics & gynecology. 2014;53(1):21-5.

Singla RK, Bhat VG. Crocin: an overview. Indo Global Journal of Pharmaceutical Sciences. 2011;1(4):281-6.

Al-Snafi AE. The pharmacology of Crocus sativus-A review. IOSR Journal of Pharmacy. 2016;6(6):8-38.

Hosseinzadeh H, Nassiri‐Asl M. Avicenna's (Ibn Sina) the canon of medicine and saffron (Crocus sativus): a review. Phytotherapy Research. 2013;27(4):475-83.

Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine. 2008;15(6):491-5.

Heidary M, RezaNejadi J, Delfan B, Birjani M, Kaviani H, Givrad S. Effect of saffron on semen parameters of infertile men . Urology Journal. 2008;24(2):255-9.

Modabbernia A, Sohrabi H, Nasehi A-A, Raisi F, Saroukhani S, Jamshidi A, et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology. 2012;223(4):381-8.

Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L.(saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009;16(8):690-3.

Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, et al. Saffron for treatment of fluoxetine‐induced sexual dysfunction in women: randomized double‐blind placebo‐controlled study. Human Psychopharmacology: Clinical and Experimental. 2013;28(1):54-60.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.