Tehran University of Medical Sciences Nursing Practice Today 2383-1154 8 4 2021 05 24 265 272 Sanghee Kim College of Nursing, Keimyung University, Daegu, South Korea 2021 02 08 2021 03 23 Background & Aim: Life after middle age accounts for almost half of the life cycle, along with global increases in life expectancy, it is important to manage the life satisfaction of middle-aged women as they transition from adulthood to old age. This study sought to investigate the life satisfaction of middle-aged women and identify the factors affecting them in various ways. Methods & Materials: As secondary research, sample data were sourced from the 2016 Korean Longitudinal Study of Aging -sixth wave of KLoSA- by the Ministry of Employment and Labor, and the Korean Employment Information Service in Korea. Results: Factors affecting the life satisfaction of middle-aged women include individual factors such as religion, household income, marriage, and educational background (all p<.05); health-related factors such as depression, and smoking; family-related factors such as frequent contact with nonresident children; and socio-cultural factors such as leisure activity or trips (all p<.05). Conclusion: The life satisfaction and influencing factors for middle-aged women identified in this study should be used as a basis for successful and healthy aging preparation in women’s health policy. https://npt.tums.ac.ir/index.php/npt/article/view/1462 https://npt.tums.ac.ir/index.php/npt/article/download/1462/500