Tehran University of Medical Sciences Nursing Practice Today 2383-1154 9 3 2022 06 13 211 220 Fatemeh Khoshnavay Fomani Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran Jila Mirlashari Women's Health Research Institute, University of British Columbia, Vancouver, Canada AND School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran Hamid Sharif Nia School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran Jamalodin Begjani School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran Farzaneh Khoshakhlagh School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran AND Nursing Faculty, Alborz University of Medical Sciences, Karaj, Iran Maryam Shiri School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran AND Nursing Faculty, Alborz University of Medical Sciences, Karaj, Iran Erfan Teymuri School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran 2021 11 07 2022 02 21 Background & Aim: Despite the well-known benefits of practicing self-reflection in educational settings, little is known regarding the effects of applying it in clinical settings. The objective of the current study was to investigate the effects of self-reflective practice on cognitive emotion regulation and resilience of mothers of preterm infants in the NICU. Methods & Materials: A total of 90 mothers whose preterm infants were admitted to NICU enrolled in the current non-randomized clinical trial study by convenience sampling (n=45 in each group). The data of the control group were gathered prior to the intervention group. Pre- and post-test data were gathered using the demographic questionnaire, the Cognitive Emotion Regulation Questionnaire, and the Conner and Davidson Resilience Scale. Self–reflection practice was designed and conducted based on the Gibbs' reflective cycle for the intervention group, which applied a blended model (face-to-face and virtual). Statistical analysis was conducted by SPSS-25 and using the repeated measure ANOVA. Results: Using ANCOVA, the results indicated that the self-reflection practice was effective in improving cognitive emotion regulation (F=66.01, P≤0.001, Eta=0.60) and resilience (F=89.43, P≤0.001, Eta= 0.67) among mothers in the intervention group.  Conclusion: Self-reflection practice was an effective intervention for improving mothers’ skills, helping them be more resilient, and assisting them in regulating their emotions. Further studies should support the current study findings in different clinical settings. https://npt.tums.ac.ir/index.php/npt/article/view/1804 https://npt.tums.ac.ir/index.php/npt/article/download/1804/536