Tehran University of Medical Sciences Nursing Practice Today 2383-1154 10 2 2023 04 25 164 172 Suarnianti Suarnianti Department of Nursing Science, Nani Hasanuddin Health Institute, Makassar, Indonesia Yusran Haskas Department of Nursing Science, Nani Hasanuddin Health Institute, Makassar, Indonesia 2022 11 11 2023 02 01 Background & Aim: Nurses worldwide face serious challenges to deal with infectious diseases. A transmission prevention model is expected to be a strategy to overcome these challenges. To date, most of the available models are in the form of disease prevention models primarily implemented to detect infections. In contrast, only a few models are implemented to improve disease transmission prevention behavior, especially in nurses. This study aims to find a model of infection transmission prevention adopted from the aids risk reduction model. Methods & Materials: This study was an analytic observational study and employed a cross-sectional approach. This study was conducted in two hospitals in Makassar City and involved 123 respondents. The data were analyzed using multiple linear regression tests. Results: This study finds that there is a correlation between organizational factors and nurses' commitment (b=.268) (p=.003); there is a correlation between self-justification and nurses’ self-labelling as at-risk individuals of contracting the disease (b=-.180 )(p=.049); there is a correlation between labeling and actions to reduce the risk of disease transmission (Enactment) (b=.255)(p=.001); there is a correlation between nurses' commitment and enactment (b=.651)(p=.001). Conclusion: The risk reduction model could represent the nurses' disease transmission prevention behavior. https://npt.tums.ac.ir/index.php/npt/article/view/2267 https://npt.tums.ac.ir/index.php/npt/article/download/2267/573