Tehran University of Medical Sciences Nursing Practice Today 2383-1154 0 0 2026 05 20 4463 4463 Siriwan Turongruang Faculty of Nursing Science, North Bangkok University, Bangkok, Thailand Pacharapon Thanamee Faculty of Nursing Science, North Bangkok University, Bangkok, Thailand 2025 09 13 2026 04 25 Background & Aim: Patients undergoing cardiac catheterization commonly experience elevated anxiety, illness uncertainty, and self-care challenges. This study evaluated the effectiveness of an integrated nursing program on anxiety, uncertainty in illness, and self-care ability among patients undergoing first-time cardiac catheterization. Methods & Materials: A quasi-experimental study with repeated measures was conducted among 60 middle-aged adults (40–65 years) scheduled for first-time cardiac catheterization at a tertiary hospital in Bangkok, Thailand. Participants were consecutively enrolled and allocated using systematic alternating assignment (intervention n=30; control n=30). The intervention comprised a four-phase integrated nursing program based on Mishel's Uncertainty Theory and Orem's Self-Care Theory. Primary outcomes were measured using STAI, MUIS-A, and SCHFI at four time points. Results: Baseline characteristics revealed no significant differences between groups (p>0.05). Mixed ANOVA revealed significant Group × Time interaction effects for all primary outcomes: anxiety [F(3,174)=39.796, p<.001, ηp²=0.407], uncertainty in illness [F(3,174)=13.827, p<.001, ηp²=0.193], and self-care ability [F(3,174)=4.485, p=.005, ηp²=0.072]. The intervention group demonstrated progressive reductions in anxiety and uncertainty in illness alongside sustained improvements in self-care ability. The intervention group experienced fewer complications (3.3% vs. 20.0%, p=0.044) and higher satisfaction scores (142.8±6.2 vs. 118.5±8.7, p<0.001). Conclusion: The integrated nursing program effectively reduced anxiety and uncertainty while enhancing self-care ability among cardiac catheterization patients, demonstrating clinical utility for improving perioperative outcomes. Trial Registration: Thai Clinical Trials Registry (Registration pending - Request No. TCTR 20260210) https://npt.tums.ac.ir/index.php/npt/article/view/4463