Medication safety and rare side effect of carbamazepine: A case report
,
Abstract
Introduction: Medicines are the most widely used interventions in health care and adverse drug reactions alone are responsible for 5-10% of hospitalizations in elderly patients. Carbamazepine is an anticonvulsant drug and skin rash is one of its rare symptoms of it. It requires immediate medical attention and is sometimes life-threatening.
Case Report: This case report is about a 72-year-old woman who witnessed the interaction of rivaroxaban and carbamazepine, and the side effects of carbamazepine simultaneously.
Conclusion: Patient participation and patient-centered tools are needed to promote patient safety.
1. World Patient Safety Day 17 September 2022 [Internet]. WHO. 2022 [cited 2022 Sep 18]. Available from: https://www.who.int/campaigns/world-patient-safety-day/2022
2. Kratz T, Diefenbacher A. Psychopharmacological treatment in older people: avoiding drug interactions and polypharmacy. Deutsches Ärzteblatt International. 2019 Jul;116(29-30):508.
3. Organization WH. Medication without harm [Internet]. World Health Organization; 2017. Available from: https://www.who.int/initiatives/medication-without-harm
4. Kadivar M, Manookian A, Asghari F, Niknafs N, Okazi A, Zarvani A. Ethical and legal aspects of patient’s safety: A clinical case report. Journal of Medical Ethics and History of Medicine. 2017;10.
5. Entringer S. Carbamazepine [Internet]. [cited 2022 Sep 16]. Available from: https://www.drugs.com/carbamazepine.html
6. Cunha JP. TEGRETOL [Internet]. [cited 2022 Oct 5]. Available from: https://www.rxlist.com/tegretol-drug.htm#description
7. Subakumar K, Franklin BD, Garfield S. Analysis of the third WHO Global Safety Challenge ‘Medication Without Harm’patient-facing materials: exploratory descriptive study. European Journal of Hospital Pharmacy. 2021 Nov 1;28(e1):e109-14.
8. Before you take it. [Internet]. WHO. 2022 [cited 2022 Sep 18]. Available from: https://cdn.who.int/media/docs/default-source/world-patient-safety-day/masters-a2-patients-posters-v1-ok.pdf?sfvrsn=abd895b4_1
9. Before you give it [Internet]. WHO. 2022. Available from: https://cdn.who.int/media/docs/default-source/world-patient-safety-day/masters-a2-hp-posters-en-v1.pdf?sfvrsn=42625135_1
10. Carbamazepine (Oral Route) Print [Internet]. [cited 2022 Oct 5]. Available from: https://www.mayoclinic.org/drugs-supplements/carbamazepine-oral-route/side-effects/drg-20062739
11. Carbamazepine ER Side Effects by Likelihood and Severity [Internet]. [cited 2022 Oct 5]. Available from: https://www.webmd.com/drugs/2/drug-1493-9005/carbamazepine-oral/carbamazepine-extended-release-oral/details/list-sideeffects
12. McTier L, Botti M, Duke M. Patient participation in medication safety during an acute care admission. Health Expectations. 2015 Oct;18(5):1744-56.
13. Mohsin-Shaikh S, Garfield S, Franklin BD. Patient involvement in medication safety in hospital: an exploratory study. International Journal of Clinical Pharmacy. 2014 Jun;36(3):657-66.
14. Stöllberger C, Finsterer J. Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy. Neurologia Neurochirurgia Polska. 2017;51(2):194-6.
15. Risselada AJ, Visser MJ, Van Roon E. Pulmonary embolism due to interaction between rivaroxaban and carbamazepine. Nederlands Tijdschrift voor Geneeskunde. 2013 Jan 1;157(52):A6568
16. Candeloro M, Eikelboom JW, Chan N, Bhagirath V, Douketis JD, Schulman S. Carbamazepine, phenytoin, and oral anticoagulants: Drug‐drug interaction and clinical events in a retrospective cohort. Research and Practice in Thrombosis and Haemostasis. 2022 Feb;6(2):e12650.
17. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatrics. 2017 Dec;17(1):1-10.
18. Golchin N, Frank SH, Vince A, Isham L, Meropol SB. Polypharmacy in the elderly. J Res Pharm Pract. 2015;4(2):85-8.
19. Medication Without Harm: Real-life stories [Internet]. [cited 2022 Oct 5]. Available from: https://www.who.int/news-room/photo-story/photo-story-detail/medication-without-harm-real-life-stories-change
2. Kratz T, Diefenbacher A. Psychopharmacological treatment in older people: avoiding drug interactions and polypharmacy. Deutsches Ärzteblatt International. 2019 Jul;116(29-30):508.
3. Organization WH. Medication without harm [Internet]. World Health Organization; 2017. Available from: https://www.who.int/initiatives/medication-without-harm
4. Kadivar M, Manookian A, Asghari F, Niknafs N, Okazi A, Zarvani A. Ethical and legal aspects of patient’s safety: A clinical case report. Journal of Medical Ethics and History of Medicine. 2017;10.
5. Entringer S. Carbamazepine [Internet]. [cited 2022 Sep 16]. Available from: https://www.drugs.com/carbamazepine.html
6. Cunha JP. TEGRETOL [Internet]. [cited 2022 Oct 5]. Available from: https://www.rxlist.com/tegretol-drug.htm#description
7. Subakumar K, Franklin BD, Garfield S. Analysis of the third WHO Global Safety Challenge ‘Medication Without Harm’patient-facing materials: exploratory descriptive study. European Journal of Hospital Pharmacy. 2021 Nov 1;28(e1):e109-14.
8. Before you take it. [Internet]. WHO. 2022 [cited 2022 Sep 18]. Available from: https://cdn.who.int/media/docs/default-source/world-patient-safety-day/masters-a2-patients-posters-v1-ok.pdf?sfvrsn=abd895b4_1
9. Before you give it [Internet]. WHO. 2022. Available from: https://cdn.who.int/media/docs/default-source/world-patient-safety-day/masters-a2-hp-posters-en-v1.pdf?sfvrsn=42625135_1
10. Carbamazepine (Oral Route) Print [Internet]. [cited 2022 Oct 5]. Available from: https://www.mayoclinic.org/drugs-supplements/carbamazepine-oral-route/side-effects/drg-20062739
11. Carbamazepine ER Side Effects by Likelihood and Severity [Internet]. [cited 2022 Oct 5]. Available from: https://www.webmd.com/drugs/2/drug-1493-9005/carbamazepine-oral/carbamazepine-extended-release-oral/details/list-sideeffects
12. McTier L, Botti M, Duke M. Patient participation in medication safety during an acute care admission. Health Expectations. 2015 Oct;18(5):1744-56.
13. Mohsin-Shaikh S, Garfield S, Franklin BD. Patient involvement in medication safety in hospital: an exploratory study. International Journal of Clinical Pharmacy. 2014 Jun;36(3):657-66.
14. Stöllberger C, Finsterer J. Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy. Neurologia Neurochirurgia Polska. 2017;51(2):194-6.
15. Risselada AJ, Visser MJ, Van Roon E. Pulmonary embolism due to interaction between rivaroxaban and carbamazepine. Nederlands Tijdschrift voor Geneeskunde. 2013 Jan 1;157(52):A6568
16. Candeloro M, Eikelboom JW, Chan N, Bhagirath V, Douketis JD, Schulman S. Carbamazepine, phenytoin, and oral anticoagulants: Drug‐drug interaction and clinical events in a retrospective cohort. Research and Practice in Thrombosis and Haemostasis. 2022 Feb;6(2):e12650.
17. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatrics. 2017 Dec;17(1):1-10.
18. Golchin N, Frank SH, Vince A, Isham L, Meropol SB. Polypharmacy in the elderly. J Res Pharm Pract. 2015;4(2):85-8.
19. Medication Without Harm: Real-life stories [Internet]. [cited 2022 Oct 5]. Available from: https://www.who.int/news-room/photo-story/photo-story-detail/medication-without-harm-real-life-stories-change
| Files | ||
| Issue | Vol 10 No 1 (2023): Winter | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/npt.v10i1.12251 | |
| Keywords | ||
| medication safety; patient safety; carbamazepine; patient participation | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Yazdani Z, Roofeh S. Medication safety and rare side effect of carbamazepine: A case report. NPT. 2023;10(1):4-6.
