The impact of negative pressure wound therapy on surgical site infection rates in obese women following cesarean section: A systematic review and meta‐analysis
,
Abstract
Background & Aim: This study aims to assess the surgical site infection (SSI) rate in obese women undergoing C-sections, comparing negative pressure wound therapy (NPWT) and standard dressings.
Methods & Materials: In this systematic review and meta-analysis, databases including Science Direct, Medline/PubMed, Web of Science, Scopus, and Cochrane Library were searched for articles published up to January 2024. The selection criteria included randomized controlled trials and cohort studies comparing the effect of (NPWT) with standard dressings on wound complications in women with obesity undergoing C-sections. Data collection and analysis Pooled effect sizes were calculated using random effects models based on heterogeneity.
Results: Out of 20 included studies, 18 reported SSI rates, which included 9243 cases and showed that NPWT reduces the rate of SSIs in obese women undergoing C-section (RR: 0.8, 95% CI: 0.66–0.96, I2 = 24.5%, P = 0.01). An in-depth examination of 13 high-quality studies, in which NPWT devices were used, reveals a pooled Mantel-Haenszel (M-H) Risk Ratio (RR) of 0.92 for Prevention- Reduction - Epithelialization- Vacuum- Environment- Negative pressure- Advanced (PREVENA) (95% CI: 0.67–1.26, I2 = 0%, P = 0.6) and 0.76 for Pressure- Incision- Closed- Optimization (PICO) (95% CI: 0.44–1.33, I2= 15%, P= 0.05), with a significant difference among devices (P=0.05).
Conclusion: NPWT reduces the SSI rate in obese women undergoing C-sections, regardless of the type or device used. Economic evaluations are crucial to justify NPWT device costs against expenses for treating surgical infections, supporting its widespread use in infection prevention.
1. Gonzalez MG, Barske ME, Kjellsson KB, Saboda K, Reed HA, Hill MG. Topical negative pressure wound therapy to prevent wound complications following caesarean delivery in high‐risk obstetric patients: A randomized controlled trial. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2023 Aug;63(4):516-20.
2. Widiyanto A, Putri SI, Fajriah AS, Peristiowati Y, Dian A, Ellina JT. The effect of prophylactic negative pressure wound therapy on infection in obese women after C-section: A meta-analysis. Berkala Ilmu Kedokteran. 2023;55(1):86-98.
3. Zejnullahu VA, Isjanovska R, Sejfija Z, Zejnullahu VA. Surgical site infections after cesarean sections at the University Clinical Center of Kosovo: rates, microbiological profile and risk factors. BMC Infectious Diseases. 2019;19(1):752.
4. Hyldig N, Vinter CA, Kruse M, Mogensen O, Bille C, Sorensen JA, Lamont RF, Wu C, Heidemann LN, Ibsen MH, Laursen JB. Prophylactic incisional negative pressure wound therapy reduces the risk of surgical site infection after caesarean section in obese women: a pragmatic randomised clinical trial. BJOG: An International Journal of Obstetrics & Gynaecology. 2019 Apr;126(5):628-35.
5. Imcha M, Liew NC, McNally A, Zibar D, O’Riordan M, Currie A, Styche T, Hughes J, Whittall C. Single-use negative pressure wound therapy to prevent surgical site complications in high-risk patients undergoing caesarean sections: a real-world study. International Journal for Quality in Health Care. 2023 Oct 1;35(4):mzad089.
6. Gomaa K, Abdelraheim AR, El Gelany S, Khalifa EM, Yousef AM, Hassan H. Incidence, risk factors and management of post cesarean section surgical site infection (SSI) in a tertiary hospital in Egypt: a five year retrospective study. BMC Pregnancy and Childbirth. 2021 Dec;21:634.
7. Abdallah DY, Jadaan MM, McCabe JP. Body mass index and risk of surgical site infection following spine surgery: a meta-analysis. European Spine Journal. 2013 Dec;22:2800-9.
8. Yeeles H, Trinick S, Childs C, Soltani H, Farrell T. Postpartum infection in morbidly obese women after caesarean section: does early prophylactic oral antibiotic use make a difference? Open Journal of Obstetrics and Gynecology. 2014 Jun 23;2014.
9. Dias M, Dick A, Reynolds RM, Lahti-Pulkkinen M, Denison FC. Predictors of surgical site skin infection and clinical outcome at caesarean section in the very severely obese: A retrospective cohort study. PLoS One. 2019;14(6):e0216157.
10. Abdallah DY, Jadaan MM, McCabe JP. Body mass index and risk of surgical site infection following spine surgery: a meta-analysis. European Spine Journal. 2013 Dec;22:2800-9.
11. Li HZ, Xu XH, Wang DW, Lin YM, Lin N, Lu HD. Negative pressure wound therapy for surgical site infections: a systematic review and meta-analysis of randomized controlled trials. Clinical Microbiology and Infection. 2019 Nov 1;25(11):1328-38.
12. Poggio JL. Perioperative strategies to prevent surgical-site infection. Clinics in Colon and Rectal Surgery. 2013 Sep;26(03):168-73.
13. Whitty JA, Wagner AP, Kang E, Ellwood D, Chaboyer W, Kumar S, Clifton VL, Thalib L, Gillespie BM. Cost‐effectiveness of closed incision negative pressure wound therapy in preventing surgical site infection among obese women giving birth by caesarean section: An economic evaluation (DRESSING trial). Australian and New Zealand Journal of Obstetrics and Gynaecology. 2023 Oct;63(5):673-80.
14. Normandin S, Safran T, Winocour S, Chu CK, Vorstenbosch J, Murphy AM, et al. Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications. Seminars in Plastic Surgery. 2021;35(3):164-70.
15. Groenen H, Jalalzadeh H, Buis DR, Dreissen YEM, Goosen JHM, Griekspoor M, et al. Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to-date meta-analysis and trial sequential analysis. EClinicalMedicine. 2023;62:102105.
16. Nyman J, Acosta S, Monsen C, Hasselmann J, Rezk F, Andersson AC. Patients’ Experiences Using Closed Incision Negative Pressure Wound Therapy Dressing After Infra-Inguinal Vascular Surgery. Journal of Patient Experience. 2022 Aug;9:23743735221112595.
17. Nuutila K, Broomhead M, Proppe K, Eriksson E. Study comparing platform wound dressing, a negative-pressure device without a filler, with three conventional negative-pressure wound therapy systems in the treatment of excisional and incisional wounds. Plastic and Reconstructive Surgery. 2021 Jan 1;147(1):76-86.
18. Torrano L, López S, Pons G. Latest Applications of Negative Pressure Wound Therapy. In: Maruccia M, Papa G, Ricci E, Giudice G, editors. Pearls and Pitfalls in Skin Ulcer Management. Cham: Springer International Publishing; 2023.
19. Global Guidelines for the Prevention of Surgical Site Infection. Geneva: World Health Organization; 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536404/.
20. Health NIf, Excellence C. PICO negative pressure wound dressings for closed surgical incisions. Medical Technologies Guidance. 2019:1-16.
21. Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surgery. 2017;152(8):784-91.
22. Sway A, Solomkin JS, Pittet D, Kilpatrick C. Methodology and background for the World Health Organization global guidelines on the prevention of surgical site infection. Surgical Infections. 2018 Jan 1;19(1):33-9.
23. Angarita AM, Jayakumaran J, Di Mascio D, Berghella V. Prophylactic negative pressure wound therapy on wound complications after cesarean delivery in women with obesity: A meta-analysis of randomized controlled trials. American Journal of Obstetrics & Gynecology MFM. 2022 May 1;4(3):100617.
24. Huang HP, Zhao WJ, Pu J, He F. Prophylactic negative pressure wound therapy for surgical site infection in obese women undergoing cesarean section: an evidence synthesis with trial sequential analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2021 Aug 3;34(15):2498-505.
25. Goldman T, Costa B. A Systematic Review and Meta-analysis of Two Negative Pressure Wound Therapy Devices to Manage Cesarean Section Incisions. American Journal of Perinatology. 2023 Sep 19.
26. Gillespie BM, Thalib L, Ellwood D, Kang E, Mahomed K, Kumar S, et al. Effect of negative-pressure wound therapy on wound complications in obese women after caesarean birth: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. 2022;129(2):196-207.
27. Tian Y, Li K, Zeng L. A systematic review with meta-analysis on prophylactic negative pressure wound therapy versus standard dressing for obese women after caesarean section. Nursing Open. 2023;10(9):5999-6013.
28. Zhu Y, Dai L, Luo B, Zhang L. Meta-analysis of prophylactic negative pressure wound therapy for surgical site infections (SSI) in caesarean section surgery. Wideochirurgia I Inne Techniki Maloinwazyjne. 2023;18(2):224-34.
29. Arian M, Valinejadi A, Soleimani M. Quality of Life in Heart Patients Receiving Telerehabilitation: An Overview with Meta-Analyses. Iranian Journal of Public Health. 2022;51(11):2388-403.
30. Arian M, Valinejadi A, Soleimani M. Reviews Evaluating Information Technology-Based Cardiac Rehabilitation Programs and Support: A Systematic Review. Iranian Journal of Public Health. 2022;51(7):1525-37.
31. Arian M, Hajiabadi F, Amini Z, Oghazian MB, Valinejadi A, Sahebkar A. Introduction of Various Models of Palliative Oncology Care: A Systematic Review. Reviews on Recent Clinical Trials. 2024 May 1;19(2):109-26.
32. Moola S, Munn Z, Sears K, Sfetcu R, Currie M, Lisy K, Tufanaru C, Qureshi R, Mattis P, Mu P. Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach. JBI Evidence Implementation. 2015 Sep 1;13(3):163-9.
33. Kawakita T, Iqbal SN, Desale S, Overcash RT. 540: Negative pressure wound therapy (PICO) in morbidly obese women after cesarean delivery compared with standard dressing. American Journal of Obstetrics & Gynecology. 2018 Jan 1;218(1):S323.
34. Ruhstaller K, Downes KL, Chandrasekaran S, Srinivas S, Durnwald C. Prophylactic wound vacuum therapy after cesarean section to prevent wound complications in the obese population: a randomized controlled trial (the ProVac study). American Journal of Perinatology. 2017 Sep;34(11):1125-30.
35. Tuuli MG, Martin S, Stout MJ, Steiner HL, Harper LM, Longo S, et al. 412: Pilot randomized trial of prophylactic negative pressure wound therapy in obese women after cesarean delivery. American Journal of Obstetrics & Gynecology. 2017;216(1):S245.
36. Mark KS, Alger L, Terplan M. Incisional negative pressure therapy to prevent wound complications following cesarean section in morbidly obese women: A pilot study. Surgical Innovation. 2014 Aug;21(4):345-9.
37. Stitely M. Prevention of wound complications after cesarean delivery in obese women utilizing negative pressure wound therapy. ClinicalTrials Gov Identifier: NCT00654641. 2013.
38. Shiroky J, Lillie E, Muaddi H, Sevigny M, Choi WJ, Karanicolas PJ. The impact of negative pressure wound therapy for closed surgical incisions on surgical site infection: A systematic review and meta-analysis. Surgery. 2020;167(6):1001-9.
39. Strugala V, Martin R. Meta-analysis of comparative trials evaluating a prophylactic single-use negative pressure wound therapy system for the prevention of surgical site complications. Surgical Infections. 2017;18(7):810-9.
40. Wells CI, Ratnayake CBB, Perrin J, Pandanaboyana S. Prophylactic Negative Pressure Wound Therapy in Closed Abdominal Incisions: A Meta-analysis of Randomised Controlled Trials. World Journal of Surgery. 2019;43(11):2779-88.
41. Smid MC, Dotters-Katz SK, Grace M, Wright ST, Villers MS, Hardy-Fairbanks A, et al. Prophylactic negative pressure wound therapy for obese women after cesarean delivery: A systematic review and meta-analysis. Obstetrics and Gynecology. 2017;130(5):969-78.
42. Tran BN, Johnson AR, Shen C, Lee BT, Lee ES. Closed-incision negative-pressure therapy efficacy in abdominal wall reconstruction in high-risk patients: a meta-analysis. Journal of Surgical Research. 2019 Sep 1;241:63-71.
43. Chaboyer W, Anderson V, Webster J, Sneddon A, Thalib L, Gillespie BM. Negative Pressure Wound Therapy on Surgical Site Infections in Women Undergoing Elective Caesarean Sections: A Pilot RCT. Healthcare (Basel). 2014;2(4):417-28.
44. Swift SH, Zimmerman MB, Hardy-Fairbanks AJ. Effect of single-use negative pressure wound therapy on postcesarean infections and wound complications for high-risk patients. The Journal of Reproductive Medicine. 2015 May 1;60(5-6):211-8.
45. Orth TA, Gerkovich MM, Heitmann E, Overcash J, Gibbs C, Parrish M. Cesarean delivery with external negative pressure dressing system: a retrospective cohort study. The Surgery Journal. 2016 Jul;2(03):e59-65.
46. Gunatilake RP, Swamy GK, Brancazio LR, Smrtka MP, Thompson JL, Gilner JB, Gray BA, Heine RP. Closed-incision negative-pressure therapy in obese patients undergoing cesarean delivery: a randomized controlled trial. American Journal of Perinatology Reports. 2017 Jul;7(03):e151-7.
47. Villers MS, Hopkins MK, Harris BS, Brancazio LR, Grotegut CA, Heine RP. 341: negative pressure wound therapy reduces cesarean delivery surgical site infections in morbidly obese women. American Journal of Obstetrics & Gynecology. 2017;216(1):S207.
48. Looby MA, Vogel RI, Bangdiwala A, Hyer B, Das K. Prophylactic negative pressure wound therapy in obese patients following cesarean delivery. Surgical Innovation. 2018 Feb;25(1):43-9.
49. Roberts S. Negatve Pressure Wound Therapy in Cesarean Secton (NPWTCS). Available at: htps://www.clinicaltrials.gov/ct2/show/NCT02289157?term=Negatve+Pressure+Wound +Therapy&recrs=e&rslt=With&cond=Cesarean+secton&rank=2. Accessed January 30, 2019. 2019.
50. Wihbey KA, Joyce EM, Spalding ZT, Jones HJ, MacKenzie TA, Evans RH, et al. Prophylactic Negative Pressure Wound Therapy and Wound Complication After Cesarean Delivery in Women With Class II or III Obesity: A Randomized Controlled Trial. Obstetrics & Gynecology. 2018;132(2).
51. Hussamy DJ, Wortman AC, McIntire DD, Leveno KJ, Casey BM, Roberts SW. Closed incision negative pressure therapy in morbidly obese women undergoing cesarean delivery: a randomized controlled trial. Obstetrics & Gynecology. 2019 Oct 1;134(4):781-9.
52. Tuuli MG, Liu J, Tita ATN, Longo S, Trudell A, Carter EB, et al. Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound Dressing on Surgical-Site Infection in Obese Women After Cesarean Delivery: A Randomized Clinical Trial. JAMA. 2020;324(12):1180-9.
53. Brigid MG, Joan W, David E, Lukman T, Jennifer AW, Kassam M, et al. Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial. BMJ. 2021;373:n893.
54. Kawakita T, Iqbal SN, Overcash RT. Negative pressure wound therapy system in extremely obese women after cesarean delivery compared with standard dressing. The Journal of Maternal-Fetal & Neonatal Medicine. 2021 Feb 16;34(4):634-8.
55. Peterson AT, Bakaysa SL, Driscoll JM, Kalyanaraman R, House MD. Randomized controlled trial of single-use negative-pressure wound therapy dressings in morbidly obese patients undergoing cesarean delivery. American Journal of Obstetrics & Gynecology MFM. 2021 Sep 1;3(5):100410.
2. Widiyanto A, Putri SI, Fajriah AS, Peristiowati Y, Dian A, Ellina JT. The effect of prophylactic negative pressure wound therapy on infection in obese women after C-section: A meta-analysis. Berkala Ilmu Kedokteran. 2023;55(1):86-98.
3. Zejnullahu VA, Isjanovska R, Sejfija Z, Zejnullahu VA. Surgical site infections after cesarean sections at the University Clinical Center of Kosovo: rates, microbiological profile and risk factors. BMC Infectious Diseases. 2019;19(1):752.
4. Hyldig N, Vinter CA, Kruse M, Mogensen O, Bille C, Sorensen JA, Lamont RF, Wu C, Heidemann LN, Ibsen MH, Laursen JB. Prophylactic incisional negative pressure wound therapy reduces the risk of surgical site infection after caesarean section in obese women: a pragmatic randomised clinical trial. BJOG: An International Journal of Obstetrics & Gynaecology. 2019 Apr;126(5):628-35.
5. Imcha M, Liew NC, McNally A, Zibar D, O’Riordan M, Currie A, Styche T, Hughes J, Whittall C. Single-use negative pressure wound therapy to prevent surgical site complications in high-risk patients undergoing caesarean sections: a real-world study. International Journal for Quality in Health Care. 2023 Oct 1;35(4):mzad089.
6. Gomaa K, Abdelraheim AR, El Gelany S, Khalifa EM, Yousef AM, Hassan H. Incidence, risk factors and management of post cesarean section surgical site infection (SSI) in a tertiary hospital in Egypt: a five year retrospective study. BMC Pregnancy and Childbirth. 2021 Dec;21:634.
7. Abdallah DY, Jadaan MM, McCabe JP. Body mass index and risk of surgical site infection following spine surgery: a meta-analysis. European Spine Journal. 2013 Dec;22:2800-9.
8. Yeeles H, Trinick S, Childs C, Soltani H, Farrell T. Postpartum infection in morbidly obese women after caesarean section: does early prophylactic oral antibiotic use make a difference? Open Journal of Obstetrics and Gynecology. 2014 Jun 23;2014.
9. Dias M, Dick A, Reynolds RM, Lahti-Pulkkinen M, Denison FC. Predictors of surgical site skin infection and clinical outcome at caesarean section in the very severely obese: A retrospective cohort study. PLoS One. 2019;14(6):e0216157.
10. Abdallah DY, Jadaan MM, McCabe JP. Body mass index and risk of surgical site infection following spine surgery: a meta-analysis. European Spine Journal. 2013 Dec;22:2800-9.
11. Li HZ, Xu XH, Wang DW, Lin YM, Lin N, Lu HD. Negative pressure wound therapy for surgical site infections: a systematic review and meta-analysis of randomized controlled trials. Clinical Microbiology and Infection. 2019 Nov 1;25(11):1328-38.
12. Poggio JL. Perioperative strategies to prevent surgical-site infection. Clinics in Colon and Rectal Surgery. 2013 Sep;26(03):168-73.
13. Whitty JA, Wagner AP, Kang E, Ellwood D, Chaboyer W, Kumar S, Clifton VL, Thalib L, Gillespie BM. Cost‐effectiveness of closed incision negative pressure wound therapy in preventing surgical site infection among obese women giving birth by caesarean section: An economic evaluation (DRESSING trial). Australian and New Zealand Journal of Obstetrics and Gynaecology. 2023 Oct;63(5):673-80.
14. Normandin S, Safran T, Winocour S, Chu CK, Vorstenbosch J, Murphy AM, et al. Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications. Seminars in Plastic Surgery. 2021;35(3):164-70.
15. Groenen H, Jalalzadeh H, Buis DR, Dreissen YEM, Goosen JHM, Griekspoor M, et al. Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to-date meta-analysis and trial sequential analysis. EClinicalMedicine. 2023;62:102105.
16. Nyman J, Acosta S, Monsen C, Hasselmann J, Rezk F, Andersson AC. Patients’ Experiences Using Closed Incision Negative Pressure Wound Therapy Dressing After Infra-Inguinal Vascular Surgery. Journal of Patient Experience. 2022 Aug;9:23743735221112595.
17. Nuutila K, Broomhead M, Proppe K, Eriksson E. Study comparing platform wound dressing, a negative-pressure device without a filler, with three conventional negative-pressure wound therapy systems in the treatment of excisional and incisional wounds. Plastic and Reconstructive Surgery. 2021 Jan 1;147(1):76-86.
18. Torrano L, López S, Pons G. Latest Applications of Negative Pressure Wound Therapy. In: Maruccia M, Papa G, Ricci E, Giudice G, editors. Pearls and Pitfalls in Skin Ulcer Management. Cham: Springer International Publishing; 2023.
19. Global Guidelines for the Prevention of Surgical Site Infection. Geneva: World Health Organization; 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536404/.
20. Health NIf, Excellence C. PICO negative pressure wound dressings for closed surgical incisions. Medical Technologies Guidance. 2019:1-16.
21. Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surgery. 2017;152(8):784-91.
22. Sway A, Solomkin JS, Pittet D, Kilpatrick C. Methodology and background for the World Health Organization global guidelines on the prevention of surgical site infection. Surgical Infections. 2018 Jan 1;19(1):33-9.
23. Angarita AM, Jayakumaran J, Di Mascio D, Berghella V. Prophylactic negative pressure wound therapy on wound complications after cesarean delivery in women with obesity: A meta-analysis of randomized controlled trials. American Journal of Obstetrics & Gynecology MFM. 2022 May 1;4(3):100617.
24. Huang HP, Zhao WJ, Pu J, He F. Prophylactic negative pressure wound therapy for surgical site infection in obese women undergoing cesarean section: an evidence synthesis with trial sequential analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2021 Aug 3;34(15):2498-505.
25. Goldman T, Costa B. A Systematic Review and Meta-analysis of Two Negative Pressure Wound Therapy Devices to Manage Cesarean Section Incisions. American Journal of Perinatology. 2023 Sep 19.
26. Gillespie BM, Thalib L, Ellwood D, Kang E, Mahomed K, Kumar S, et al. Effect of negative-pressure wound therapy on wound complications in obese women after caesarean birth: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. 2022;129(2):196-207.
27. Tian Y, Li K, Zeng L. A systematic review with meta-analysis on prophylactic negative pressure wound therapy versus standard dressing for obese women after caesarean section. Nursing Open. 2023;10(9):5999-6013.
28. Zhu Y, Dai L, Luo B, Zhang L. Meta-analysis of prophylactic negative pressure wound therapy for surgical site infections (SSI) in caesarean section surgery. Wideochirurgia I Inne Techniki Maloinwazyjne. 2023;18(2):224-34.
29. Arian M, Valinejadi A, Soleimani M. Quality of Life in Heart Patients Receiving Telerehabilitation: An Overview with Meta-Analyses. Iranian Journal of Public Health. 2022;51(11):2388-403.
30. Arian M, Valinejadi A, Soleimani M. Reviews Evaluating Information Technology-Based Cardiac Rehabilitation Programs and Support: A Systematic Review. Iranian Journal of Public Health. 2022;51(7):1525-37.
31. Arian M, Hajiabadi F, Amini Z, Oghazian MB, Valinejadi A, Sahebkar A. Introduction of Various Models of Palliative Oncology Care: A Systematic Review. Reviews on Recent Clinical Trials. 2024 May 1;19(2):109-26.
32. Moola S, Munn Z, Sears K, Sfetcu R, Currie M, Lisy K, Tufanaru C, Qureshi R, Mattis P, Mu P. Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach. JBI Evidence Implementation. 2015 Sep 1;13(3):163-9.
33. Kawakita T, Iqbal SN, Desale S, Overcash RT. 540: Negative pressure wound therapy (PICO) in morbidly obese women after cesarean delivery compared with standard dressing. American Journal of Obstetrics & Gynecology. 2018 Jan 1;218(1):S323.
34. Ruhstaller K, Downes KL, Chandrasekaran S, Srinivas S, Durnwald C. Prophylactic wound vacuum therapy after cesarean section to prevent wound complications in the obese population: a randomized controlled trial (the ProVac study). American Journal of Perinatology. 2017 Sep;34(11):1125-30.
35. Tuuli MG, Martin S, Stout MJ, Steiner HL, Harper LM, Longo S, et al. 412: Pilot randomized trial of prophylactic negative pressure wound therapy in obese women after cesarean delivery. American Journal of Obstetrics & Gynecology. 2017;216(1):S245.
36. Mark KS, Alger L, Terplan M. Incisional negative pressure therapy to prevent wound complications following cesarean section in morbidly obese women: A pilot study. Surgical Innovation. 2014 Aug;21(4):345-9.
37. Stitely M. Prevention of wound complications after cesarean delivery in obese women utilizing negative pressure wound therapy. ClinicalTrials Gov Identifier: NCT00654641. 2013.
38. Shiroky J, Lillie E, Muaddi H, Sevigny M, Choi WJ, Karanicolas PJ. The impact of negative pressure wound therapy for closed surgical incisions on surgical site infection: A systematic review and meta-analysis. Surgery. 2020;167(6):1001-9.
39. Strugala V, Martin R. Meta-analysis of comparative trials evaluating a prophylactic single-use negative pressure wound therapy system for the prevention of surgical site complications. Surgical Infections. 2017;18(7):810-9.
40. Wells CI, Ratnayake CBB, Perrin J, Pandanaboyana S. Prophylactic Negative Pressure Wound Therapy in Closed Abdominal Incisions: A Meta-analysis of Randomised Controlled Trials. World Journal of Surgery. 2019;43(11):2779-88.
41. Smid MC, Dotters-Katz SK, Grace M, Wright ST, Villers MS, Hardy-Fairbanks A, et al. Prophylactic negative pressure wound therapy for obese women after cesarean delivery: A systematic review and meta-analysis. Obstetrics and Gynecology. 2017;130(5):969-78.
42. Tran BN, Johnson AR, Shen C, Lee BT, Lee ES. Closed-incision negative-pressure therapy efficacy in abdominal wall reconstruction in high-risk patients: a meta-analysis. Journal of Surgical Research. 2019 Sep 1;241:63-71.
43. Chaboyer W, Anderson V, Webster J, Sneddon A, Thalib L, Gillespie BM. Negative Pressure Wound Therapy on Surgical Site Infections in Women Undergoing Elective Caesarean Sections: A Pilot RCT. Healthcare (Basel). 2014;2(4):417-28.
44. Swift SH, Zimmerman MB, Hardy-Fairbanks AJ. Effect of single-use negative pressure wound therapy on postcesarean infections and wound complications for high-risk patients. The Journal of Reproductive Medicine. 2015 May 1;60(5-6):211-8.
45. Orth TA, Gerkovich MM, Heitmann E, Overcash J, Gibbs C, Parrish M. Cesarean delivery with external negative pressure dressing system: a retrospective cohort study. The Surgery Journal. 2016 Jul;2(03):e59-65.
46. Gunatilake RP, Swamy GK, Brancazio LR, Smrtka MP, Thompson JL, Gilner JB, Gray BA, Heine RP. Closed-incision negative-pressure therapy in obese patients undergoing cesarean delivery: a randomized controlled trial. American Journal of Perinatology Reports. 2017 Jul;7(03):e151-7.
47. Villers MS, Hopkins MK, Harris BS, Brancazio LR, Grotegut CA, Heine RP. 341: negative pressure wound therapy reduces cesarean delivery surgical site infections in morbidly obese women. American Journal of Obstetrics & Gynecology. 2017;216(1):S207.
48. Looby MA, Vogel RI, Bangdiwala A, Hyer B, Das K. Prophylactic negative pressure wound therapy in obese patients following cesarean delivery. Surgical Innovation. 2018 Feb;25(1):43-9.
49. Roberts S. Negatve Pressure Wound Therapy in Cesarean Secton (NPWTCS). Available at: htps://www.clinicaltrials.gov/ct2/show/NCT02289157?term=Negatve+Pressure+Wound +Therapy&recrs=e&rslt=With&cond=Cesarean+secton&rank=2. Accessed January 30, 2019. 2019.
50. Wihbey KA, Joyce EM, Spalding ZT, Jones HJ, MacKenzie TA, Evans RH, et al. Prophylactic Negative Pressure Wound Therapy and Wound Complication After Cesarean Delivery in Women With Class II or III Obesity: A Randomized Controlled Trial. Obstetrics & Gynecology. 2018;132(2).
51. Hussamy DJ, Wortman AC, McIntire DD, Leveno KJ, Casey BM, Roberts SW. Closed incision negative pressure therapy in morbidly obese women undergoing cesarean delivery: a randomized controlled trial. Obstetrics & Gynecology. 2019 Oct 1;134(4):781-9.
52. Tuuli MG, Liu J, Tita ATN, Longo S, Trudell A, Carter EB, et al. Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound Dressing on Surgical-Site Infection in Obese Women After Cesarean Delivery: A Randomized Clinical Trial. JAMA. 2020;324(12):1180-9.
53. Brigid MG, Joan W, David E, Lukman T, Jennifer AW, Kassam M, et al. Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial. BMJ. 2021;373:n893.
54. Kawakita T, Iqbal SN, Overcash RT. Negative pressure wound therapy system in extremely obese women after cesarean delivery compared with standard dressing. The Journal of Maternal-Fetal & Neonatal Medicine. 2021 Feb 16;34(4):634-8.
55. Peterson AT, Bakaysa SL, Driscoll JM, Kalyanaraman R, House MD. Randomized controlled trial of single-use negative-pressure wound therapy dressings in morbidly obese patients undergoing cesarean delivery. American Journal of Obstetrics & Gynecology MFM. 2021 Sep 1;3(5):100410.
| Files | ||
| Issue | Vol 11 No 3 (2024): Summer | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/npt.v11i3.16169 | |
| Keywords | ||
| surgical site infection obese cesarean section meta‐analysis | ||
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How to Cite
1.
Arian M, Kamali A. The impact of negative pressure wound therapy on surgical site infection rates in obese women following cesarean section: A systematic review and meta‐analysis. NPT. 2024;11(3):207-223.
