Dermatology life quality index in vitiligo patients: A systematic review and meta-analysis of observational studies
-
Reza Ghanei Gheshlagh
,
Kamel Abdi
,
Mojtaba Jafari
,
Pegah Dalvand
,
Sholeh Saedmocheshi
,
Asra Nassehi
Abstract
Background & Aim: Vitiligo is a chronic and unpredictable condition. The absence of effective treatments, coupled with fears of rejection and stigma, can adversely affect patients' coping abilities and their social and psychological adjustment. This study aimed to assess the overall quality of life score of vitiligo patients using DLQI to evaluate the disease's impact on their quality of life.
Methods & Materials: This meta-analysis adhered to PRISMA 2020 guidelines and thoroughly searched the PubMed, EMBASE, Web of Science/ISI, and Scopus databases from their inception to January 2023. All observational studies reporting the quality of life score based on the DLQI were included in the analysis. Heterogeneity among the studies was assessed using the I2 index and Cochrane’s Q-statistic. Data were analyzed using the random effects model using STATA software version 12.
Results: Our analysis included a total of 58 studies involving 9277 individuals. The pooled DLQI score was 8.07 (95% CI: 7.22-8.91). The lowest and highest scores were observed in Europe (5.52, 95% CI: 4.18-6.87) and Africa (10.95, 95% CI: 7.77-14.15), respectively. The DLQI score was 7.17 (95% CI: 6.04-8.31) in men and 8.63 (95% CI: 7.44-9.82) in women. No significant correlation was found between the DLQI score and the publication year of the articles (p=0.219), patients’ age (p=0.119), and disease duration (p=0.203).
Conclusion: Vitiligo moderately impacts patients' quality of life. Therefore, it seems necessary to provide psychological and social training for these patients.
1. Yang Y-T, Hsu C-H, Wang Y-F, Chang Y-J, Yang H-J, Ko J-L, et al. Worsening quality of life in young adult, highly educated, and married female patients with vitiligo: A hospital-based case-control study in Taiwan. International Journal of Environmental Research Public Health. 2022;19(11):6741.
2. Belgaumkar VA CR, Deshmukh NS, Warke NV. Impact of Vitiligo on Quality of Life: A cross-sectional pilot sudy from western India. Journal of Skin and Stem Cell. 2020;7(2):1-8.
3. Silpa-Archa N, Pruksaeakanan C, Angkoolpakdeekul N, Chaiyabutr C, Kulthanan K, Ratta-Apha W, et al. Relationship between depression and quality of life among vitiligo patients: A self-assessment questionnaire-based study. Clinical, Cosmetic Investigational Dermatology. 2020:511-20.
4. Faria AR, Tarlé RG, Dellatorre G, Mira MT, Castro CCSd. Vitiligo-Part 2-classification, histopathology and treatment. Anais Brasileiros de Dermatologia. 2014;89:784-90.
5. Şenol A, Yücelten AD, Ay P. Development of a quality of life scale for vitiligo. Dermatology. 2013;226(2):185-90.
6. Wang G, Qiu D, Yang H, Liu W. The prevalence and odds of depression in patients with vitiligo: A meta‐analysis. Journal of the European Academy of Dermatology Venereology. 2018;32(8):1343-51.
7. Parsad D, Pandhi R, Dogra S, Kanwar A, Kumar B. Dermatology Life Quality Index score in vitiligo and its impact on the treatment outcome. British Journal of Dermatology. 2003;148(2):373-4.
8. Thompson A, Clarke S, Newell RJ, Gawkrodger D. Vitiligo linked to stigmatization in British South Asian women: A qualitative study of the experiences of living with vitiligo. British Journal of Dermatology. 2010;163(3):481-6.
9. Kiprono S CB, Makwaya C, Naafs B, Masenga J. Quality of life of patients with vitiligo attending the Regional Dermatology Training Center in Northern Tanzania. International Journal of Dermatology. 2013;52(2):191-4.
10. Tan I. Gender Disparities in Vitiligo: Psychological Effects and QoL. 2024.
11. Anderson RT, Rajagopalan R. Development and validation of a quality of life instrument for cutaneous diseases. Journal of the American Academy of Dermatology. 1997;37(1):41-50.
12. Chren M-M, Lasek RJ, Quinn LM, Mostow EN, Zyzanski SJ. Skindex, a quality-of-life measure for patients with skin disease: Reliability, validity, and responsiveness. Journal of Investigative Dermatology. 1996;107(5):707-13.
13. Morgan M, McCreedy R, Simpson J, Hay RJ. Dermatology quality of life scales–a measure of the impact of skin diseases. British Journal of Dermatology. 1997;136(2):202-6.
14. Evers A, Duller P, Van De Kerkhof P, Van der Valk P, De Jong E, Gerritsen M, et al. The Impact of Chronic Skin Disease on Daily Life (ISDL): A generic and dermatology‐specific health instrument. British Journal of Dermatology. 2008;158(1):101-8.
15. Finlay AY, Khan G. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clinical Experimental Dermatology. 1994;19(3):210-6.
16. Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? Journal of Investigative Dermatology. 2005;125(4):659-64.
17. Basra M, Fenech R, Gatt R, Salek M, Finlay AY. The Dermatology Life Quality Index 1994–2007: a comprehensive review of validation data and clinical results. British Journal of Dermatology. 2008;159(5):997-1035.
18. Amer AA, Gao XH. Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades. International Journal of Dermatology. 2016;55(6):608-14.
19. Vrijman C, Homan MWL, Limpens J, van der Veen W, Wolkerstorfer A, Terwee CB, et al. Measurement properties of outcome measures for vitiligo: a systematic review. Archives of dermatology. 2012;148(11):1302-9.
20. Pattinson RL T-SN, Gupta S, Henry AL, Lavallée JF, Otten M, Pickles T, Courtier N, Austin J, Janus C, Augustin M. Patient-reported outcome measures in dermatology: A systematic review. Acta Dermato-Venereologica 2021;101(9):1-10.
21. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372.
22. Dreier M. Quality assessment in meta-analysis: Assessing the validity of study outcomes. Methods of clinical epidemiology: Springer; 2013. p. 213-28.
23. Luchini C, Stubbs B, Solmi M, Veronese N. Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale. World Journal of Meta-Analysis. 2017;5(4):80-4.
24. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European journal of epidemiology. 2010;25:603-5.
25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Statistics in medicine. 2002;21(11):1539-58.
26. Benny D, Makkuni A, Thyvalappil A, Mathew P, Sridharan R, Druhin A. Quality of life and psychiatric comorbidity in vitiligo: A hospital-based cross-sectional study from a tertiary care center in South India. Journal of Dermatology Dermatologic Surgery. 2021;25(2):114.
27. Mishra N, Rastogi MK, Gahalaut P, Agrawal S. Dermatology specific quality of life in vitiligo patients and its relation with various variables: A hospital-based cross-sectional study. Journal of Clinical Diagnostic Research: JCDR. 2014;8(6):YC01.
28. Eltaher SM, Araby EM. Health-related quality of life in patients with vitiligo. Egyptian Journal of Community Medicine. 2015;33(2).
29. Lacerda KAP, Silva LA, Mendonca GS, Guimarães RA, Guilo LA. Association between quality of life and perceived stress in patients with vitiligo: A case-control study. Bioscience Journal. 2020:1032-42.
30. Wang KY WK, Zhang ZP. Health‐related quality of life and marital quality of vitiligo patients in China. Journal of the European Academy of Dermatology and Venereology 2011;25(4):429-35.
31. Chan MF CT, Goh BK, Aw CW, Thng TG, Lee SM. Investigating factors associated with depression of vitiligo patients in Singapore. Journal of Clinical Nursing 2012;21(11-12):614-21.
32. Chan MF, Thng TG, Aw CW, Goh BK, Lee SM, Chua TL. Investigating factors associated with quality of life of vitiligo patients in Singapore. International Journal of Nursing Practice. 2013 Sep;19:3-10.
33. Hooshmand AM, Shayan NA. Impact of vitiligo on quality of life of patients in Herat, Afghanistan. Iranian Journal of Dermatology. 2021;24(3):220-6.
34. Mashayekhi V, Javidi Z, Kiafar B, Manteghi AA, Saadatian V, Esmaeili HA, et al. Quality of life in patients with vitiligo: A descriptive study on 83 patients attending a PUVA therapy unit in Imam Reza Hospital, Mashad. Indian Journal of Dermatology, Venereology Leprology. 2010;76:592.
35. Bin Saif GA, Al-Balbeesi AO, Binshabaib R, Alsaad D, Kwatra SG, Alzolibani AA, et al. Quality of life in family members of vitiligo patients: A questionnaire study in Saudi Arabia. American Journal of Clinical Dermatology. 2013;14:489-95.
36. Fawzy MM HR. Impact of vitiligo on the health-related quality of life of 104 adult patients, using Dermatology Life Quality Index and stress score: First Egyptian report. European Journal of Dermatology. 2013;23(5):733-4.
37. Silverberg JI SN. Association between vitiligo extent and distribution and quality-of-life impairment. JAMA Dermatology 2013;149(2):159-64.
38. Sarhan D, Mohammed GF, Gomaa AH, Eyada MM. Female genital dialogues: female genital self-image, sexual dysfunction, and quality of life in patients with vitiligo with and without genital affection. Journal of Sex Marital Therapy. 2016;42(3):267-76.
39. Amatya B PD. Assessment and comparison of quality of life in patients with melasma and vitiligo. Kathmandu University Medical Journal. 2019;66(2):114-8.
40. Hammam MA, Yasien HA, Algharably AF. Effect of Vitiligo Area Scoring Index on the quality of life in patients with vitiligo. Menoufia Medical Journal. 2019;32(1):244.
41. Ghajarzadeh M, Ghiasi M, Kheirkhah S. Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. Acta Medica Iranica. 2012:511-5.
42. Kota RS, Vora RV, Varma JR, Kota SK, Patel TM, Ganjiwale J. Study on assessment of quality of life and depression in patients of vitiligo. Indian Dermatology Online Journal. 2019;10(2):153.
43. Radtke M, Schäfer I, Gajur A, Langenbruch A, Augustin M. Willingness‐to‐pay and quality of life in patients with vitiligo. British Journal of Dermatology. 2009;161(1):134-9.
44. Sangma LN, Nath J, Bhagabati D. Quality of life and psychological morbidity in vitiligo patients: A study in a teaching hospital from north-East India. Indian Journal of Dermatology, Venereology. 2015;60(2):142.
45. Sawant NS, Vanjari NA, Khopkar U. Gender differences in depression, coping, stigma, and quality of life in patients of vitiligo. Dermatology Research Practice. 2019;2019.
46. Nazar I, Kamran F, Masood A. Psychosocial predictors of quality of life in patients with vitiligo. Pakistan Journal of Psychological Research. 2021;36(1):19-36.
47. Zandi S FS, Saberi N. . Effect of vitiligo on self-reported quality of life in Southern part of Iran. Journal of Pakistan Association of Dermatologists. 2011;21(1):4-9.
48. Rao NN TR, Ahmad A. Correlation of Dermatology Life Quality Index and Vitiligo Extent Tensity Index: A cross-sectional study. Journal of Clinical & Diagnostic Research. 2022;16(12):1-4.
49. Yang TT LC, Lan CC. Impact of Vitiligo on Life Quality of Patients: Assessment of Currently Available Tools. International Journal of Environmental Research and Public Health 2022;19(22):14943.
50. Hussain A SM, Tariq H, Kanwal A, Mehwish A, Tariq A. . Assessment of Impact of Vitiligo on Quality of life of Patients using Dermatology Life Quality Index (DLQI). Journal of Pakistan Association of Dermatologists 2022;32(1):47-51.
51. Baidya S DP, Mohanty R. Assessment of quality of life in vitiligo patients attending a tertiary care hospital-A cross-sectional study. Industrial Psychiatry Journal 2021;30(1):62.
52. Atış G TA, Ferhatoğlu ZA, Göktay F, Yaşar Ş, Aytekin S. . Type D personality and quality of life in alopecia areata and vitiligo patients: A cross-sectional study in a Turkish population. Turkderm Turk Arch Derm Venereol. 2021;55:87-91.
53. Agarwal S JC, Shaafie HI, Khalid A, Singh A. . Impact on quality of life of family members of vitiligo patients in North India: A cross-sectional study using family dermatology life quality index. Indian Journal of Dermatology, Venereology and Leprology. 2021;87(6):869-72.
54. Dabas G VK, Parsad D, Kumar A, Kumaran MS. Psychological disturbances in patients with pigmentary disorders: a cross‐sectional study. Journal of the European Academy of Dermatology and Venereology 2020;34(2):392-9.
55. ZS A-D. Quality of Life in Vitiligo Patients and Its Relation To Various Variables in Duhok, Kurdistan Region, Iraq. Duhok Medical Journal 2020;14(1):44-52.
56. Abdelmaguid EM, Khalifa H, Salah MM, Sayed DS. Assessment of depression and anxiety about quality of life in patients with vitiligo. Egyptian Journal of Dermatology Venerology. 2020;40(2):99.
57. Anaba EL, Oaku RI. A prospective cross-sectional study of quality of life of vitiligo patients using a vitiligo-specific quality of life instrument. West African Journal of Medicine. 2020 Dec 1;37(7):745-9.
58. Gupta V, Sreenivas V, Mehta M, Ramam M. What do Vitiligo Impact Scale‐22 scores mean? Studying the clinical interpretation of scores using an anchor‐based approach. British Journal of Dermatology. 2019 Mar 1;180(3):580-5.
59. Temel AB BS, Senol Y, Alpsoy E. Internalized stigma in patients with acne vulgaris, vitiligo, and alopecia areata. Turkish Journal of Dermatology. 2019;13(3):109.
60. Hassanin AM IN, El Guindi A, Sowailam HA. The emotional burden of chronic skin disease dominates physical factors among women, adversely affecting quality of life and sexual function. Journal of Psychosomatic Research. 2018;115:53-7.
61. Xu ST OE, Kim JE, Ko JY, Ro YS. Comparative study of quality of life between psoriasis, vitiligo, and autoimmune bullous disease. Hong Kong Journal of Dermatology & Venereology. 2017;25(2):57-64.
62. Morales-Sánchez MA V-SM, Peralta-Pedrero ML, Olguín-García MG, Jurado-Santa Cruz F. . Impact of vitiligo on quality of life. Actas Dermo-Sifiliográficas (English Edition). 2017;108(17):637-42.
63. Salman A, Kurt E, Topcuoglu V, Demircay Z. Social anxiety and quality of life in vitiligo and acne patients with facial involvement: a cross-sectional controlled study. American Journal of Clinical Dermatology. 2016;17:305-11.
64. Ezzedine K GP, Meurant JM, Seneschal J, Léauté‐Labrèze C, Ballanger F, Jouary T, Taïeb C, Taïeb A. Living with vitiligo: Results from a national survey indicate differences between skin phototypes. British Journal of Dermatology 2015;173(2):607-9.
65. Aradhya SS, Manjunath K, Somaiah S. Quality-of-life and psychosocial impact of vitiligo in Indian patients. Pigment International. 2015;2(1):28.
66. Ingordo V, Cazzaniga S, Medri M, Raone B, Digiuseppe MD, Musumeci ML, et al. To what extent is quality of life impaired in vitiligo? A multicenter study on Italian patients using the dermatology life quality index. Dermatology. 2014;229(3):240-7.
67. Ghaderi R, Saadatjoo A. Evaluating of life quality in Iranian patients with vitiligo using generic and special questionnaires. Shiraz E-Medical Journal. 2014;15(3).
68. Yanik ME, Erfan G, Albayrak Y, Aydin M, Kulac M, Kuloglu M. Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo. Neuropsychiatric Disease Treatment. 2014:2361-7.
69. Gupta V, Sreenivas V, Mehta M, Khaitan BK, Ramam M. Measurement properties of the Vitiligo Impact Scale‐22 (VIS‐22), a vitiligo‐specific quality‐of‐life instrument. British Journal of Dermatology. 2014 Nov 1;171(5):1084-90.
70. Kaçar SD, Özuğuz P, Bağcıoğlu E, Coșkun K, Polat S, Karaca Ș. Is a poor Dermatology Life Quality Index score a sign of stigmatization in patients with vitiligo? Türkiye Klinikleri Dermatoloji Dergisi. 2014;24(2):45-50.
71. Wong SM BR. Quality of life among Malaysian patients with vitiligo. International Journal of Dermatology 2012;51(2):158-61.
72. Ingordo V CS, Gentile C, Iannazzone SS, Cusano F, Naldi L. Dermatology Life Quality Index score in vitiligo patients: a pilot study among young Italian males. Italian Journal of Dermatology and Venereology. 2012;147(1):83-90.
73. Kostopoulou P JT, Quintard B, Ezzedine K, Marques S, Boutchnei S, Taieb A. Objective vs. subjective factors in the psychological impact of vitiligo: the experience from a French referral center. British Journal of Dermatology. 2009;161(1):128-33.
74. Dolatshahi M, Ghazi P, Feizy V, Hemami MR. Life quality assessment among patients with vitiligo: comparison of married and single patients in Iran. Indian Journal of Dermatology, Venereology and Leprology. 2008;74(6):700.
75. Al Robaee AA. Assessment of quality of life in Saudi patients with vitiligo in a medical school in Qassim province, Saudi Arabia. Saudi Medical Journal. 2007 Sep 1;28(9):1414-7.
76. Ongenae K, Van Geel N, De Schepper S, Naeyaert J-M. Effect of vitiligo on self‐reported health‐related quality of life. British Journal of Dermatology. 2005;152(6):1165-72.
77. Aghaei S, Sodaifi M, Jafari P, Mazharinia N, Finlay AY. DLQI scores in vitiligo: reliability and validity of the Persian version. BMC Dermatology. 2004;4:1-5.
78. Kent G, Al‐Abadie M. Factors affecting responses on Dermatology Life Quality Index items among vitiligo sufferers. Clinical and Experimental Dermatology. 1996 Sep;21(5):330-3.
79. Krüger C, Schallreuter KU. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. International Journal of Dermatology. 2012;51(10):1206-12.
80. Jafferany M, & Franca, K. Psychodermatology: A comprehensive review of skin conditions influenced by mental health. American Journal of Clinical Dermatology. 2020;21(2):181-90.
2. Belgaumkar VA CR, Deshmukh NS, Warke NV. Impact of Vitiligo on Quality of Life: A cross-sectional pilot sudy from western India. Journal of Skin and Stem Cell. 2020;7(2):1-8.
3. Silpa-Archa N, Pruksaeakanan C, Angkoolpakdeekul N, Chaiyabutr C, Kulthanan K, Ratta-Apha W, et al. Relationship between depression and quality of life among vitiligo patients: A self-assessment questionnaire-based study. Clinical, Cosmetic Investigational Dermatology. 2020:511-20.
4. Faria AR, Tarlé RG, Dellatorre G, Mira MT, Castro CCSd. Vitiligo-Part 2-classification, histopathology and treatment. Anais Brasileiros de Dermatologia. 2014;89:784-90.
5. Şenol A, Yücelten AD, Ay P. Development of a quality of life scale for vitiligo. Dermatology. 2013;226(2):185-90.
6. Wang G, Qiu D, Yang H, Liu W. The prevalence and odds of depression in patients with vitiligo: A meta‐analysis. Journal of the European Academy of Dermatology Venereology. 2018;32(8):1343-51.
7. Parsad D, Pandhi R, Dogra S, Kanwar A, Kumar B. Dermatology Life Quality Index score in vitiligo and its impact on the treatment outcome. British Journal of Dermatology. 2003;148(2):373-4.
8. Thompson A, Clarke S, Newell RJ, Gawkrodger D. Vitiligo linked to stigmatization in British South Asian women: A qualitative study of the experiences of living with vitiligo. British Journal of Dermatology. 2010;163(3):481-6.
9. Kiprono S CB, Makwaya C, Naafs B, Masenga J. Quality of life of patients with vitiligo attending the Regional Dermatology Training Center in Northern Tanzania. International Journal of Dermatology. 2013;52(2):191-4.
10. Tan I. Gender Disparities in Vitiligo: Psychological Effects and QoL. 2024.
11. Anderson RT, Rajagopalan R. Development and validation of a quality of life instrument for cutaneous diseases. Journal of the American Academy of Dermatology. 1997;37(1):41-50.
12. Chren M-M, Lasek RJ, Quinn LM, Mostow EN, Zyzanski SJ. Skindex, a quality-of-life measure for patients with skin disease: Reliability, validity, and responsiveness. Journal of Investigative Dermatology. 1996;107(5):707-13.
13. Morgan M, McCreedy R, Simpson J, Hay RJ. Dermatology quality of life scales–a measure of the impact of skin diseases. British Journal of Dermatology. 1997;136(2):202-6.
14. Evers A, Duller P, Van De Kerkhof P, Van der Valk P, De Jong E, Gerritsen M, et al. The Impact of Chronic Skin Disease on Daily Life (ISDL): A generic and dermatology‐specific health instrument. British Journal of Dermatology. 2008;158(1):101-8.
15. Finlay AY, Khan G. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clinical Experimental Dermatology. 1994;19(3):210-6.
16. Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? Journal of Investigative Dermatology. 2005;125(4):659-64.
17. Basra M, Fenech R, Gatt R, Salek M, Finlay AY. The Dermatology Life Quality Index 1994–2007: a comprehensive review of validation data and clinical results. British Journal of Dermatology. 2008;159(5):997-1035.
18. Amer AA, Gao XH. Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades. International Journal of Dermatology. 2016;55(6):608-14.
19. Vrijman C, Homan MWL, Limpens J, van der Veen W, Wolkerstorfer A, Terwee CB, et al. Measurement properties of outcome measures for vitiligo: a systematic review. Archives of dermatology. 2012;148(11):1302-9.
20. Pattinson RL T-SN, Gupta S, Henry AL, Lavallée JF, Otten M, Pickles T, Courtier N, Austin J, Janus C, Augustin M. Patient-reported outcome measures in dermatology: A systematic review. Acta Dermato-Venereologica 2021;101(9):1-10.
21. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372.
22. Dreier M. Quality assessment in meta-analysis: Assessing the validity of study outcomes. Methods of clinical epidemiology: Springer; 2013. p. 213-28.
23. Luchini C, Stubbs B, Solmi M, Veronese N. Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale. World Journal of Meta-Analysis. 2017;5(4):80-4.
24. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European journal of epidemiology. 2010;25:603-5.
25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Statistics in medicine. 2002;21(11):1539-58.
26. Benny D, Makkuni A, Thyvalappil A, Mathew P, Sridharan R, Druhin A. Quality of life and psychiatric comorbidity in vitiligo: A hospital-based cross-sectional study from a tertiary care center in South India. Journal of Dermatology Dermatologic Surgery. 2021;25(2):114.
27. Mishra N, Rastogi MK, Gahalaut P, Agrawal S. Dermatology specific quality of life in vitiligo patients and its relation with various variables: A hospital-based cross-sectional study. Journal of Clinical Diagnostic Research: JCDR. 2014;8(6):YC01.
28. Eltaher SM, Araby EM. Health-related quality of life in patients with vitiligo. Egyptian Journal of Community Medicine. 2015;33(2).
29. Lacerda KAP, Silva LA, Mendonca GS, Guimarães RA, Guilo LA. Association between quality of life and perceived stress in patients with vitiligo: A case-control study. Bioscience Journal. 2020:1032-42.
30. Wang KY WK, Zhang ZP. Health‐related quality of life and marital quality of vitiligo patients in China. Journal of the European Academy of Dermatology and Venereology 2011;25(4):429-35.
31. Chan MF CT, Goh BK, Aw CW, Thng TG, Lee SM. Investigating factors associated with depression of vitiligo patients in Singapore. Journal of Clinical Nursing 2012;21(11-12):614-21.
32. Chan MF, Thng TG, Aw CW, Goh BK, Lee SM, Chua TL. Investigating factors associated with quality of life of vitiligo patients in Singapore. International Journal of Nursing Practice. 2013 Sep;19:3-10.
33. Hooshmand AM, Shayan NA. Impact of vitiligo on quality of life of patients in Herat, Afghanistan. Iranian Journal of Dermatology. 2021;24(3):220-6.
34. Mashayekhi V, Javidi Z, Kiafar B, Manteghi AA, Saadatian V, Esmaeili HA, et al. Quality of life in patients with vitiligo: A descriptive study on 83 patients attending a PUVA therapy unit in Imam Reza Hospital, Mashad. Indian Journal of Dermatology, Venereology Leprology. 2010;76:592.
35. Bin Saif GA, Al-Balbeesi AO, Binshabaib R, Alsaad D, Kwatra SG, Alzolibani AA, et al. Quality of life in family members of vitiligo patients: A questionnaire study in Saudi Arabia. American Journal of Clinical Dermatology. 2013;14:489-95.
36. Fawzy MM HR. Impact of vitiligo on the health-related quality of life of 104 adult patients, using Dermatology Life Quality Index and stress score: First Egyptian report. European Journal of Dermatology. 2013;23(5):733-4.
37. Silverberg JI SN. Association between vitiligo extent and distribution and quality-of-life impairment. JAMA Dermatology 2013;149(2):159-64.
38. Sarhan D, Mohammed GF, Gomaa AH, Eyada MM. Female genital dialogues: female genital self-image, sexual dysfunction, and quality of life in patients with vitiligo with and without genital affection. Journal of Sex Marital Therapy. 2016;42(3):267-76.
39. Amatya B PD. Assessment and comparison of quality of life in patients with melasma and vitiligo. Kathmandu University Medical Journal. 2019;66(2):114-8.
40. Hammam MA, Yasien HA, Algharably AF. Effect of Vitiligo Area Scoring Index on the quality of life in patients with vitiligo. Menoufia Medical Journal. 2019;32(1):244.
41. Ghajarzadeh M, Ghiasi M, Kheirkhah S. Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. Acta Medica Iranica. 2012:511-5.
42. Kota RS, Vora RV, Varma JR, Kota SK, Patel TM, Ganjiwale J. Study on assessment of quality of life and depression in patients of vitiligo. Indian Dermatology Online Journal. 2019;10(2):153.
43. Radtke M, Schäfer I, Gajur A, Langenbruch A, Augustin M. Willingness‐to‐pay and quality of life in patients with vitiligo. British Journal of Dermatology. 2009;161(1):134-9.
44. Sangma LN, Nath J, Bhagabati D. Quality of life and psychological morbidity in vitiligo patients: A study in a teaching hospital from north-East India. Indian Journal of Dermatology, Venereology. 2015;60(2):142.
45. Sawant NS, Vanjari NA, Khopkar U. Gender differences in depression, coping, stigma, and quality of life in patients of vitiligo. Dermatology Research Practice. 2019;2019.
46. Nazar I, Kamran F, Masood A. Psychosocial predictors of quality of life in patients with vitiligo. Pakistan Journal of Psychological Research. 2021;36(1):19-36.
47. Zandi S FS, Saberi N. . Effect of vitiligo on self-reported quality of life in Southern part of Iran. Journal of Pakistan Association of Dermatologists. 2011;21(1):4-9.
48. Rao NN TR, Ahmad A. Correlation of Dermatology Life Quality Index and Vitiligo Extent Tensity Index: A cross-sectional study. Journal of Clinical & Diagnostic Research. 2022;16(12):1-4.
49. Yang TT LC, Lan CC. Impact of Vitiligo on Life Quality of Patients: Assessment of Currently Available Tools. International Journal of Environmental Research and Public Health 2022;19(22):14943.
50. Hussain A SM, Tariq H, Kanwal A, Mehwish A, Tariq A. . Assessment of Impact of Vitiligo on Quality of life of Patients using Dermatology Life Quality Index (DLQI). Journal of Pakistan Association of Dermatologists 2022;32(1):47-51.
51. Baidya S DP, Mohanty R. Assessment of quality of life in vitiligo patients attending a tertiary care hospital-A cross-sectional study. Industrial Psychiatry Journal 2021;30(1):62.
52. Atış G TA, Ferhatoğlu ZA, Göktay F, Yaşar Ş, Aytekin S. . Type D personality and quality of life in alopecia areata and vitiligo patients: A cross-sectional study in a Turkish population. Turkderm Turk Arch Derm Venereol. 2021;55:87-91.
53. Agarwal S JC, Shaafie HI, Khalid A, Singh A. . Impact on quality of life of family members of vitiligo patients in North India: A cross-sectional study using family dermatology life quality index. Indian Journal of Dermatology, Venereology and Leprology. 2021;87(6):869-72.
54. Dabas G VK, Parsad D, Kumar A, Kumaran MS. Psychological disturbances in patients with pigmentary disorders: a cross‐sectional study. Journal of the European Academy of Dermatology and Venereology 2020;34(2):392-9.
55. ZS A-D. Quality of Life in Vitiligo Patients and Its Relation To Various Variables in Duhok, Kurdistan Region, Iraq. Duhok Medical Journal 2020;14(1):44-52.
56. Abdelmaguid EM, Khalifa H, Salah MM, Sayed DS. Assessment of depression and anxiety about quality of life in patients with vitiligo. Egyptian Journal of Dermatology Venerology. 2020;40(2):99.
57. Anaba EL, Oaku RI. A prospective cross-sectional study of quality of life of vitiligo patients using a vitiligo-specific quality of life instrument. West African Journal of Medicine. 2020 Dec 1;37(7):745-9.
58. Gupta V, Sreenivas V, Mehta M, Ramam M. What do Vitiligo Impact Scale‐22 scores mean? Studying the clinical interpretation of scores using an anchor‐based approach. British Journal of Dermatology. 2019 Mar 1;180(3):580-5.
59. Temel AB BS, Senol Y, Alpsoy E. Internalized stigma in patients with acne vulgaris, vitiligo, and alopecia areata. Turkish Journal of Dermatology. 2019;13(3):109.
60. Hassanin AM IN, El Guindi A, Sowailam HA. The emotional burden of chronic skin disease dominates physical factors among women, adversely affecting quality of life and sexual function. Journal of Psychosomatic Research. 2018;115:53-7.
61. Xu ST OE, Kim JE, Ko JY, Ro YS. Comparative study of quality of life between psoriasis, vitiligo, and autoimmune bullous disease. Hong Kong Journal of Dermatology & Venereology. 2017;25(2):57-64.
62. Morales-Sánchez MA V-SM, Peralta-Pedrero ML, Olguín-García MG, Jurado-Santa Cruz F. . Impact of vitiligo on quality of life. Actas Dermo-Sifiliográficas (English Edition). 2017;108(17):637-42.
63. Salman A, Kurt E, Topcuoglu V, Demircay Z. Social anxiety and quality of life in vitiligo and acne patients with facial involvement: a cross-sectional controlled study. American Journal of Clinical Dermatology. 2016;17:305-11.
64. Ezzedine K GP, Meurant JM, Seneschal J, Léauté‐Labrèze C, Ballanger F, Jouary T, Taïeb C, Taïeb A. Living with vitiligo: Results from a national survey indicate differences between skin phototypes. British Journal of Dermatology 2015;173(2):607-9.
65. Aradhya SS, Manjunath K, Somaiah S. Quality-of-life and psychosocial impact of vitiligo in Indian patients. Pigment International. 2015;2(1):28.
66. Ingordo V, Cazzaniga S, Medri M, Raone B, Digiuseppe MD, Musumeci ML, et al. To what extent is quality of life impaired in vitiligo? A multicenter study on Italian patients using the dermatology life quality index. Dermatology. 2014;229(3):240-7.
67. Ghaderi R, Saadatjoo A. Evaluating of life quality in Iranian patients with vitiligo using generic and special questionnaires. Shiraz E-Medical Journal. 2014;15(3).
68. Yanik ME, Erfan G, Albayrak Y, Aydin M, Kulac M, Kuloglu M. Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo. Neuropsychiatric Disease Treatment. 2014:2361-7.
69. Gupta V, Sreenivas V, Mehta M, Khaitan BK, Ramam M. Measurement properties of the Vitiligo Impact Scale‐22 (VIS‐22), a vitiligo‐specific quality‐of‐life instrument. British Journal of Dermatology. 2014 Nov 1;171(5):1084-90.
70. Kaçar SD, Özuğuz P, Bağcıoğlu E, Coșkun K, Polat S, Karaca Ș. Is a poor Dermatology Life Quality Index score a sign of stigmatization in patients with vitiligo? Türkiye Klinikleri Dermatoloji Dergisi. 2014;24(2):45-50.
71. Wong SM BR. Quality of life among Malaysian patients with vitiligo. International Journal of Dermatology 2012;51(2):158-61.
72. Ingordo V CS, Gentile C, Iannazzone SS, Cusano F, Naldi L. Dermatology Life Quality Index score in vitiligo patients: a pilot study among young Italian males. Italian Journal of Dermatology and Venereology. 2012;147(1):83-90.
73. Kostopoulou P JT, Quintard B, Ezzedine K, Marques S, Boutchnei S, Taieb A. Objective vs. subjective factors in the psychological impact of vitiligo: the experience from a French referral center. British Journal of Dermatology. 2009;161(1):128-33.
74. Dolatshahi M, Ghazi P, Feizy V, Hemami MR. Life quality assessment among patients with vitiligo: comparison of married and single patients in Iran. Indian Journal of Dermatology, Venereology and Leprology. 2008;74(6):700.
75. Al Robaee AA. Assessment of quality of life in Saudi patients with vitiligo in a medical school in Qassim province, Saudi Arabia. Saudi Medical Journal. 2007 Sep 1;28(9):1414-7.
76. Ongenae K, Van Geel N, De Schepper S, Naeyaert J-M. Effect of vitiligo on self‐reported health‐related quality of life. British Journal of Dermatology. 2005;152(6):1165-72.
77. Aghaei S, Sodaifi M, Jafari P, Mazharinia N, Finlay AY. DLQI scores in vitiligo: reliability and validity of the Persian version. BMC Dermatology. 2004;4:1-5.
78. Kent G, Al‐Abadie M. Factors affecting responses on Dermatology Life Quality Index items among vitiligo sufferers. Clinical and Experimental Dermatology. 1996 Sep;21(5):330-3.
79. Krüger C, Schallreuter KU. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. International Journal of Dermatology. 2012;51(10):1206-12.
80. Jafferany M, & Franca, K. Psychodermatology: A comprehensive review of skin conditions influenced by mental health. American Journal of Clinical Dermatology. 2020;21(2):181-90.
| Files | ||
| Issue | Vol 11 No 4 (2024): Autumn | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/npt.v11i4.16811 | |
| Keywords | ||
| vitiligo; quality of life; meta-analysis | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Ghanei Gheshlagh R, Abdi K, Jafari M, Dalvand P, Saedmocheshi S, Nassehi A. Dermatology life quality index in vitiligo patients: A systematic review and meta-analysis of observational studies. NPT. 2024;11(4):316-328.
