Comparison effect of lavender oil inhalation and tea on sleep quality, fatigue, and pain in hemodialysis patients: A randomized clinical trial
-
Vahideh Aghamohammadi
,
Javad Ebadi
,
Allehe Seyyedrasooli
,
Shafagh Aliasgarzadeh
,
Musab Ghaderi
,
Alireza Khateri
,
Khadijeh Nasiri
Abstract
Background & Aim: The pain of needle insertion in arteriovenous fistula, fatigue, and sleep disturbances are common problems in hemodialysis patients. Using lavender products can help reduce these problems. This study aimed to compare the effects of lavender aromatherapy and lavender tea consumption on reducing pain and fatigue, as well as improving sleep quality in hemodialysis patients.
Methods & Materials: This study is an open-label trial conducted at the Dialysis Center at Tabriz University of Medical Science from May to December 2022. Random allocation was done by randomizing the moved blocks. hemodialysis patients were allocated to one of the three study groups: control (n=30), lavender inhalation (n=30), and lavender tea (n=30). At the baseline and the end of the study, Participants' sleep quality with PSQI, fatigue with FSS, and pain of needle insertion in arteriovenous fistula with Vas scale were assessed. The data analysis was performed using SPSS software The Analysis of covariance (ANCOVA) test was used to compare the mean of variables between the study groups.
Results: A comparison of the follow-up scores between 3 groups shows that participants in the lavender tea group and lavender aromatherapy group had a lower score of total score of PSQI (P<0.001), fatigue (P<0.001), and pain(P<0.001) following the intervention compared to the control group. Also, there was no statistically significant difference between the lavender tea group and the lavender aromatherapy group in terms of sleep quality scores (P=0.428), fatigue (P=0.570), and pain (P=0.997).
Conclusion: The findings of this study showed that lavender can be useful in improving the problems of dialysis patients, such as sleep quality, fatigue, and pain caused by needle insertion.
1. Sanyaolu A, Okorie C, Annan R, Turkey H, Akhtar N, Gray F, Nwaduwa I. Epidemiology and management of chronic renal failure: a global public health problem. Biostatistics Epidemiol Int J. 2018;1(1):11-6.
2. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases. Nephrology Dialysis Transplantation. 2019 Nov 1;34(11):1803-5.
3. Başaran D, Altun ÖŞ, Kaban F, Ecder T. Hemodiyaliz hastalarının umutsuzluk düzeylerinin değerlendirilmesi. Nefroloji Hemşireliği Dergisi. 2016;11(1):9-16.
4. da Silva FA, Silva Martins MT, Gutiérrez-Peredo GB, Kraychete AC, Penalva CC, Lopes MB, Matos CM, Lopes AA. Mortality, health-related quality of life, and depression symptoms in younger and older men and women undergoing hemodialysis. The International Journal of Artificial Organs. 2023 Sep;46(8-9):492-7.
5. Pei M, Aguiar R, Pagels AA, Heimbürger O, Stenvinkel P, Bárány P, Medin C, Jacobson SH, Hylander B, Lindholm B, Qureshi AR. Health-related quality of life as predictor of mortality in end-stage renal disease patients: An observational study. BMC Nephrology. 2019 Dec;20:1-0.
6. Aliasgharpour M, Abbaszadeh R, Mohammadi N, Kazemnejad A. Effect of lavender aromatherapy on the pain of arteriovenous fistula puncture in patients on hemodialysis. Nursing Practice Today. 2016 Nov 19;3(1):26-30.
7. Pham PC, Khaing K, Sievers TM, Pham PM, Miller JM, Pham SV, Pham PA, Pham PT. 2017 update on pain management in patients with chronic kidney disease. Clinical Kidney Journal. 2017 Oct;10(5):688-97.
8. Usta, Y.Y. And Y. Demir, Hemodiyaliz hastalarinda yorgunluğa etki eden faktörlerin değerlendirilmesi. Anatolian Journal Of Clinical Investigation, 2014. 8(1).
9. Flythe JE, Hilliard T, Lumby E, Castillo G, Orazi J, Abdel-Rahman EM, Pai AB, Rivara MB, Peter WL, Weisbord SD, Wilkie CM. Fostering innovation in symptom management among hemodialysis patients: paths forward for insomnia, muscle cramps, and fatigue. Clinical Journal of the American Society of Nephrology. 2019 Jan 1;14(1):150-60.
10. Faydalı S, Çetinkaya F. The effect of aromatherapy on sleep quality of elderly people residing in a nursing home. Holistic Nursing Practice. 2018 Jan 1;32(1):8-16.
11. Tan LH, Chen PS, Chiang HY, King E, Yeh HC, Hsiao YL, Chang DR, Chen SH, Wu MY, Kuo CC. Insomnia and poor sleep in CKD: a systematic review and meta-analysis. Kidney Medicine. 2022 May 1;4(5):100458.
12. Lee G, Bae H. Therapeutic effects of phytochemicals and medicinal herbs on depression. BioMed Research International. 2017;2017(1):6596241.
13. Taşan E, Ovayolu O, Ovayolu N. The effect of diluted lavender oil inhalation on pain development during vascular access among patients undergoing hemodialysis. Complementary Therapies in Clinical Practice. 2019 May 1;35:177-82.
14. Meneklİ T, Durmaz YÇ. Effect of lavender aromatherapy on pruritus, anxiety, and sleep quality of patients undergoing hemodialysis: a randomized controlled trial. TMR Integrative Nursing. 2021 Oct 1;5(5).
15. Souri F, Rakhshan K, Erfani S, Azizi Y, Nasseri Maleki S, Aboutaleb N. Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress. Inflammopharmacology. 2019 Aug 1;27:799-807.
16. Rahmati B, Khalili M, Roghani M, Ahghari P. Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice. Journal of Ethnopharmacology. 2013 Jun 21;148(1):152-7.
17. Bagheri-Nesami M, Espahbodi F, Nikkhah A, Shorofi SA, Charati JY. The effects of lavender aromatherapy on pain following needle insertion into a fistula in hemodialysis patients. Complementary Therapies in Clinical Practice. 2014 Feb 1;20(1):1-4.
18. Yamada K, Mimaki Y, Sashida Y. Anticonvulsive effects of inhaling lavender oil vapour. Biological and Pharmaceutical Bulletin. 1994 Feb 15;17(2):359-60.
19. McNelis, M.A., Does Lavender Aromatherapy or Tea Improve Quality of Sleep in Women? 2018.
20. Setyaningrum N, Setyawan A, Bistara DN. The effect of lavender essential oil aromatherapy on sleep quality in hemodialysis patients. Jurnal Aisyah: Jurnal Ilmu Kesehatan. 2022 Nov 20;7(S2):155-60.
21. Şahin S, Tokgöz B, Demir G. Effect of lavender aromatherapy on arteriovenous fistula puncture pain and the level of state and trait anxiety in hemodialysis patients: a randomized controlled trial. Pain Management Nursing. 2021 Aug 1;22(4):509-15.
22. Ahmady S, Rezaei M, Khatony A. Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients: A randomized trial. Complementary Therapies in Clinical Practice. 2019 Aug 1;36:64-8. 23. Kim, M., et al., Effects of lavender on anxiety, depression, and physiological parameters: Systematic review and meta-analysis. Asian nursing research, 2021. 15(5): p. 279-290.
24. Bazrafshan MR, Jokar M, Shokrpour N, Delam H. The effect of lavender herbal tea on the anxiety and depression of the elderly: a randomized clinical trial. Complementary Therapies in Medicine. 2020 May 1;50:102393.
25. Yangöz ŞT, Turan Kavradım S, Özer Z. The effect of aromatherapy on fatigue in adults receiving hemodialysis treatment: A systematic review and meta‐analysis of randomized controlled trials. Journal of Advanced Nursing. 2021 Nov;77(11):4371-86.
26. Şentürk A, Kartın PT. The effect of lavender oil application via inhalation pathway on hemodialysis patients' anxiety level and sleep quality. Holistic Nursing Practice. 2018 Nov 1;32(6):324-35.
27. Bouya S, Ahmadidarehsima S, Badakhsh M, Balouchi A. Effect of aromatherapy interventions on hemodialysis complications: a systematic review. Complementary Therapies in Clinical Practice. 2018 Aug 1;32:130-8.
28. Kamalifard M, Farshbaf-Khalili A, Namadian M, Ranjbar Y, Herizchi S. Comparison of the effect of lavender and bitter orange on sleep quality in postmenopausal women: a triple-blind, randomized, controlled clinical trial. Women & Health. 2018 Sep 14;58(8):851-65.
29. Haidari F, Aghamohammadi V, Mohammadshahi M, Ahmadi-Angali K, Asghari-Jafarabadi M. Whey protein supplementation reducing fasting levels of anandamide and 2-AG without weight loss in pre-menopausal women with obesity on a weight-loss diet. Trials. 2020 Dec;21:1-10.
30. Aghamohammadi V, Salmani R, Ivanbagha R, Effati daryani F, Nasiri K. Footbath as a safe, simple, and non‐pharmacological method to improve sleep quality of menopausal women. Research in Nursing & Health. 2020 Dec;43(6):621-8.
31. Buysse DJ, Reynolds CF, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep. 1991 Aug 1;14(4):331-8.
32. A'zimian M, Fallah-Pour M, Karimlou M. Evaluation of reliability and validity of the Persian version of Fatigue Severity Scale (FSS) among persons with multiple sclerosis. Archives of Rehabilitation. 2013 Jan 10;13(4):84-91.
33. Habibzadeh H, Dalavan OW, Alilu L, Wardle J, Khalkhali H, Nozad A. Effects of foot massage on severity of fatigue and quality of life in hemodialysis patients: a randomized controlled trial. International Journal of Community Based Nursing and Midwifery. 2020 Apr;8(2):92.
34. Beerappa H, Kavana GT, Chandrababu R. The effects of inhalational lavender essential oil aromatherapy on sleep quality in hemodialysis patients: A before-and-after-intervention trial. Holistic Nursing Practice. 2023 Nov 1;37(6):356-62.
35. Chen SL, Chen CH. Effects of Lavender tea on fatigue, depression, and maternal‐infant attachment in sleep‐disturbed postnatal women. Worldviews on Evidence‐Based Nursing. 2015 Dec;12(6):370-9.
36. Karadag E, Baglama SS. The effect of aromatherapy on fatigue and anxiety in patients undergoing hemodialysis treatment: a randomized controlled study. Holistic Nursing Practice. 2019 Jul 1;33(4):222-9.
37. Muz G, Taşcı S. Effect of aromatherapy via inhalation on the sleep quality and fatigue level in people undergoing hemodialysis. Applied Nursing Research. 2017 Oct 1;37:28-35.
38. Hassanzadeh M, Kiani F, Bouya S, Zarei M. Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis. Complementary Therapies in Clinical Practice. 2018 May 1;31:210-4.
39. Varaei S, Jalalian Z, Yekani Nejad MS, Shamsizadeh M. Comparison the effects of inhalation and massage aromatherapy with lavender and sweet orange on fatigue in hemodialysis patients: a randomized clinical trial. Journal of Complementary and Integrative Medicine. 2021 Mar 15;18(1):193-200.
40. Bagheri-Nesami M, Shorofi SA, Nikkhah A, Espahbodi F, Koolaee FS. The effects of aromatherapy with lavender essential oil on fatigue levels in hemodialysis patients: A randomized clinical trial. Complementary Therapies in Clinical Practice. 2016 Feb 1;22:33-7.
41. Arslan DE, Akça NK. The effect of aromatherapy hand massage on distress and sleep quality in hemodialysis patients: A randomized controlled trial. Complementary therapies in Clinical Practice. 2020 May 1;39:101136.
42. Elhalafawy S, Bahgat RS, Abd-Elhafez MA, Farag NH. Effect of cryotherapy versus aromatherapy on pain of arteriovenous fistula puncture for children undergoing hemodialysis. IOSR Journal of Nursing and Health Science. 2020;9(1):9-19.
43. Ghods AA, Abforosh NH, Ghorbani R, Asgari MR. The effect of topical application of lavender essential oil on the intensity of pain caused by the insertion of dialysis needles in hemodialysis patients: A randomized clinical trial. Complementary Therapies in Medicine. 2015 Jun 1;23(3):325-30.
2. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases. Nephrology Dialysis Transplantation. 2019 Nov 1;34(11):1803-5.
3. Başaran D, Altun ÖŞ, Kaban F, Ecder T. Hemodiyaliz hastalarının umutsuzluk düzeylerinin değerlendirilmesi. Nefroloji Hemşireliği Dergisi. 2016;11(1):9-16.
4. da Silva FA, Silva Martins MT, Gutiérrez-Peredo GB, Kraychete AC, Penalva CC, Lopes MB, Matos CM, Lopes AA. Mortality, health-related quality of life, and depression symptoms in younger and older men and women undergoing hemodialysis. The International Journal of Artificial Organs. 2023 Sep;46(8-9):492-7.
5. Pei M, Aguiar R, Pagels AA, Heimbürger O, Stenvinkel P, Bárány P, Medin C, Jacobson SH, Hylander B, Lindholm B, Qureshi AR. Health-related quality of life as predictor of mortality in end-stage renal disease patients: An observational study. BMC Nephrology. 2019 Dec;20:1-0.
6. Aliasgharpour M, Abbaszadeh R, Mohammadi N, Kazemnejad A. Effect of lavender aromatherapy on the pain of arteriovenous fistula puncture in patients on hemodialysis. Nursing Practice Today. 2016 Nov 19;3(1):26-30.
7. Pham PC, Khaing K, Sievers TM, Pham PM, Miller JM, Pham SV, Pham PA, Pham PT. 2017 update on pain management in patients with chronic kidney disease. Clinical Kidney Journal. 2017 Oct;10(5):688-97.
8. Usta, Y.Y. And Y. Demir, Hemodiyaliz hastalarinda yorgunluğa etki eden faktörlerin değerlendirilmesi. Anatolian Journal Of Clinical Investigation, 2014. 8(1).
9. Flythe JE, Hilliard T, Lumby E, Castillo G, Orazi J, Abdel-Rahman EM, Pai AB, Rivara MB, Peter WL, Weisbord SD, Wilkie CM. Fostering innovation in symptom management among hemodialysis patients: paths forward for insomnia, muscle cramps, and fatigue. Clinical Journal of the American Society of Nephrology. 2019 Jan 1;14(1):150-60.
10. Faydalı S, Çetinkaya F. The effect of aromatherapy on sleep quality of elderly people residing in a nursing home. Holistic Nursing Practice. 2018 Jan 1;32(1):8-16.
11. Tan LH, Chen PS, Chiang HY, King E, Yeh HC, Hsiao YL, Chang DR, Chen SH, Wu MY, Kuo CC. Insomnia and poor sleep in CKD: a systematic review and meta-analysis. Kidney Medicine. 2022 May 1;4(5):100458.
12. Lee G, Bae H. Therapeutic effects of phytochemicals and medicinal herbs on depression. BioMed Research International. 2017;2017(1):6596241.
13. Taşan E, Ovayolu O, Ovayolu N. The effect of diluted lavender oil inhalation on pain development during vascular access among patients undergoing hemodialysis. Complementary Therapies in Clinical Practice. 2019 May 1;35:177-82.
14. Meneklİ T, Durmaz YÇ. Effect of lavender aromatherapy on pruritus, anxiety, and sleep quality of patients undergoing hemodialysis: a randomized controlled trial. TMR Integrative Nursing. 2021 Oct 1;5(5).
15. Souri F, Rakhshan K, Erfani S, Azizi Y, Nasseri Maleki S, Aboutaleb N. Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress. Inflammopharmacology. 2019 Aug 1;27:799-807.
16. Rahmati B, Khalili M, Roghani M, Ahghari P. Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice. Journal of Ethnopharmacology. 2013 Jun 21;148(1):152-7.
17. Bagheri-Nesami M, Espahbodi F, Nikkhah A, Shorofi SA, Charati JY. The effects of lavender aromatherapy on pain following needle insertion into a fistula in hemodialysis patients. Complementary Therapies in Clinical Practice. 2014 Feb 1;20(1):1-4.
18. Yamada K, Mimaki Y, Sashida Y. Anticonvulsive effects of inhaling lavender oil vapour. Biological and Pharmaceutical Bulletin. 1994 Feb 15;17(2):359-60.
19. McNelis, M.A., Does Lavender Aromatherapy or Tea Improve Quality of Sleep in Women? 2018.
20. Setyaningrum N, Setyawan A, Bistara DN. The effect of lavender essential oil aromatherapy on sleep quality in hemodialysis patients. Jurnal Aisyah: Jurnal Ilmu Kesehatan. 2022 Nov 20;7(S2):155-60.
21. Şahin S, Tokgöz B, Demir G. Effect of lavender aromatherapy on arteriovenous fistula puncture pain and the level of state and trait anxiety in hemodialysis patients: a randomized controlled trial. Pain Management Nursing. 2021 Aug 1;22(4):509-15.
22. Ahmady S, Rezaei M, Khatony A. Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients: A randomized trial. Complementary Therapies in Clinical Practice. 2019 Aug 1;36:64-8. 23. Kim, M., et al., Effects of lavender on anxiety, depression, and physiological parameters: Systematic review and meta-analysis. Asian nursing research, 2021. 15(5): p. 279-290.
24. Bazrafshan MR, Jokar M, Shokrpour N, Delam H. The effect of lavender herbal tea on the anxiety and depression of the elderly: a randomized clinical trial. Complementary Therapies in Medicine. 2020 May 1;50:102393.
25. Yangöz ŞT, Turan Kavradım S, Özer Z. The effect of aromatherapy on fatigue in adults receiving hemodialysis treatment: A systematic review and meta‐analysis of randomized controlled trials. Journal of Advanced Nursing. 2021 Nov;77(11):4371-86.
26. Şentürk A, Kartın PT. The effect of lavender oil application via inhalation pathway on hemodialysis patients' anxiety level and sleep quality. Holistic Nursing Practice. 2018 Nov 1;32(6):324-35.
27. Bouya S, Ahmadidarehsima S, Badakhsh M, Balouchi A. Effect of aromatherapy interventions on hemodialysis complications: a systematic review. Complementary Therapies in Clinical Practice. 2018 Aug 1;32:130-8.
28. Kamalifard M, Farshbaf-Khalili A, Namadian M, Ranjbar Y, Herizchi S. Comparison of the effect of lavender and bitter orange on sleep quality in postmenopausal women: a triple-blind, randomized, controlled clinical trial. Women & Health. 2018 Sep 14;58(8):851-65.
29. Haidari F, Aghamohammadi V, Mohammadshahi M, Ahmadi-Angali K, Asghari-Jafarabadi M. Whey protein supplementation reducing fasting levels of anandamide and 2-AG without weight loss in pre-menopausal women with obesity on a weight-loss diet. Trials. 2020 Dec;21:1-10.
30. Aghamohammadi V, Salmani R, Ivanbagha R, Effati daryani F, Nasiri K. Footbath as a safe, simple, and non‐pharmacological method to improve sleep quality of menopausal women. Research in Nursing & Health. 2020 Dec;43(6):621-8.
31. Buysse DJ, Reynolds CF, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep. 1991 Aug 1;14(4):331-8.
32. A'zimian M, Fallah-Pour M, Karimlou M. Evaluation of reliability and validity of the Persian version of Fatigue Severity Scale (FSS) among persons with multiple sclerosis. Archives of Rehabilitation. 2013 Jan 10;13(4):84-91.
33. Habibzadeh H, Dalavan OW, Alilu L, Wardle J, Khalkhali H, Nozad A. Effects of foot massage on severity of fatigue and quality of life in hemodialysis patients: a randomized controlled trial. International Journal of Community Based Nursing and Midwifery. 2020 Apr;8(2):92.
34. Beerappa H, Kavana GT, Chandrababu R. The effects of inhalational lavender essential oil aromatherapy on sleep quality in hemodialysis patients: A before-and-after-intervention trial. Holistic Nursing Practice. 2023 Nov 1;37(6):356-62.
35. Chen SL, Chen CH. Effects of Lavender tea on fatigue, depression, and maternal‐infant attachment in sleep‐disturbed postnatal women. Worldviews on Evidence‐Based Nursing. 2015 Dec;12(6):370-9.
36. Karadag E, Baglama SS. The effect of aromatherapy on fatigue and anxiety in patients undergoing hemodialysis treatment: a randomized controlled study. Holistic Nursing Practice. 2019 Jul 1;33(4):222-9.
37. Muz G, Taşcı S. Effect of aromatherapy via inhalation on the sleep quality and fatigue level in people undergoing hemodialysis. Applied Nursing Research. 2017 Oct 1;37:28-35.
38. Hassanzadeh M, Kiani F, Bouya S, Zarei M. Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis. Complementary Therapies in Clinical Practice. 2018 May 1;31:210-4.
39. Varaei S, Jalalian Z, Yekani Nejad MS, Shamsizadeh M. Comparison the effects of inhalation and massage aromatherapy with lavender and sweet orange on fatigue in hemodialysis patients: a randomized clinical trial. Journal of Complementary and Integrative Medicine. 2021 Mar 15;18(1):193-200.
40. Bagheri-Nesami M, Shorofi SA, Nikkhah A, Espahbodi F, Koolaee FS. The effects of aromatherapy with lavender essential oil on fatigue levels in hemodialysis patients: A randomized clinical trial. Complementary Therapies in Clinical Practice. 2016 Feb 1;22:33-7.
41. Arslan DE, Akça NK. The effect of aromatherapy hand massage on distress and sleep quality in hemodialysis patients: A randomized controlled trial. Complementary therapies in Clinical Practice. 2020 May 1;39:101136.
42. Elhalafawy S, Bahgat RS, Abd-Elhafez MA, Farag NH. Effect of cryotherapy versus aromatherapy on pain of arteriovenous fistula puncture for children undergoing hemodialysis. IOSR Journal of Nursing and Health Science. 2020;9(1):9-19.
43. Ghods AA, Abforosh NH, Ghorbani R, Asgari MR. The effect of topical application of lavender essential oil on the intensity of pain caused by the insertion of dialysis needles in hemodialysis patients: A randomized clinical trial. Complementary Therapies in Medicine. 2015 Jun 1;23(3):325-30.
| Issue | Articles in Press | |
| Section | Original Article(s) | |
| Keywords | ||
| hemodialysis; lavandula; fatigue; sleep quality; pain; aromatherapy; complementary medicine | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Aghamohammadi V, Ebadi J, Seyyedrasooli A, Aliasgarzadeh S, Ghaderi M, Khateri A, Nasiri K. Comparison effect of lavender oil inhalation and tea on sleep quality, fatigue, and pain in hemodialysis patients: A randomized clinical trial. NPT. 2025;:X-X.
