The trend of infertility in Iran, an original review and meta-analysis
Abstract
Background & Aim: Worldwide prevalence of infertility has been reported to be 3-7% of all couples. There are varieties among the results of studies conducted on the prevalence of infertility in Iran. The present study aimed to evaluate the trend of infertility using meta-analysis method in Iran.
Methods & Materials: We systematically reviewed all published papers in Medline database of the National Library of Medicine and their Persian equivalents (2001–2011). Findings which met the inclusion criteria were included. Random effects meta-analysis was applied to the data of 13 selected populations. Data manipulation and statistical analyses were performed using STATA.
Results: Overall, 13 studies met our inclusion criteria. The pooled prevalence of infertility was 13.2% (95% CI: 8-18.3). The pooled prevalence of primary and secondary infertility were reported to be 5.2% (95% CI: 3.7 - 6.6) and 3.2% (95%CI: 2 - 4.4), respectively. The lowest and highest frequency of lifetime prevalence of infertility was 2.8% in 2001 and 24.9% in 2010, respectively. Meta- regression scatter plot showed an increasing trend in the prevalence of infertility during 2001- 2011 (P = 0.58). Meta-regression did not indicate a significant correlation between the sample sizes and the prevalence of infertility (P = 0.64).
Conclusion: The pooled infertility prevalence in Iran is higher than its mean worldwide, and lifetime infertility is increasing in recent years compared to the past in Iran.
Aflatoonian A, Baghianimoghadam B, Partovi P, Abdoli A, Hemmati P, Tabibnejad N, et al. A new classification for female in- fertility. Clin Exp Obstet Gynecol 2011;38(4): 379-81.
Kumar D. Prevalence of female infertility and its socio-economic factors in tribal communities of Central India. Rural Remote Health 2007; 7(2): 456.
Zegers-Hochschild F, Adamson GD, de MJ, Ishihara O, Mansour R, Nygren K, et al. In- ternational Committee for Monitoring As- sisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 2009; 92(5): 1520-4.
Inhorn MC. Global infertility and the globa- lization of new reproductive technologies: illustrations from Egypt. Soc Sci Med 2003; 56(9): 1837-51.
Millheiser LS, Helmer AE, Quintero RB, Westphal LM, Milki AA, Lathi RB. Is infer- tility a risk factor for female sexual dysfunc- tion? A case-control study. Fertil Steril 2010; 94(6): 2022-5.
Volgsten H, Skoog SA, Ekselius L, Lundkv- ist O, Sundstrom P, I. Risk factors for psy- chiatric disorders in infertile women and men undergoing in vitro fertilization treat- ment. Fertil Steril 2010; 93(4): 1088-96.
Volgsten H, Skoog SA, Ekselius L, Lundkv- ist O, Sundstrom P, I. Prevalence of psychia- tric disorders in infertile women and men undergoing in vitro fertilization treatment. Hum Reprod 2008; 23(9): 2056-63.
Jumayev I, Harun-Or-Rashid M, Rustamov O, Zakirova N, Kasuya H, Sakamoto J. So- cial correlates of female infertility in Uzbe- kistan. Nagoya J Med Sci 2012; 74(3-4): 273-83.
Mascarenhas MN, Cheung H, Mathers CD, Stevens GA. Measuring infertility in popula- tions: constructing a standard definition for use with demographic and reproductive health surveys. Popul Health Metr 2012; 10(1): 17.
Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infer- tility. Hum Reprod 2001; 16(8): 1768-76.
Naghavi M. Demographic and health survey in the Islamic Republic of Iran. Tehran, Iran: Department of Health, Ministry of Health and Medical Edu-cation; 2002. p. 45-7, 132-7. [In Persian].
Vahidi S, Ardalan A, Mohammad K. Preva- lence of primary infertility in the Islamic Republic of Iran in 2004-2005. Asia Pac J Public Health 2009; 21(3): 287-93.
Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Hum Reprod 2005; 20(5): 1144-7.
Behjati Ardekani Z, Akhondi MM, Kamali K, Fazli Khalaf Z, Eskandari Sh, Ghorbani B, et al. Mental Health Status of Patients At- tending Avicenna Infertility Clinic. J Reprod Infertil 2010; 11(4): 319-24. [In Persian].
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62(10): 1006-12.
Moghaddam A, Karimpour Malekshah A, Talebpour Amiri F, Taringou F. The preva- lence of infertility in center region of Mazan- daran province in 1999. J Mazandaran Univ Med Sci 2000; 10(27): 12-8. [In Persian].
Sadegh Moghadam L, Moslem AR, Gharche M, Chamanzari H. Study of women infertility of Gonabad. Horizon Med Sci 2008, 13(4): 82-5. [In Persian].
Nojomi M. Epidemiology of infertility in the west of Tehran in 2000. J Am Med Womens Assoc 2002; 57(4): 219.
Safarinejad M. Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int J Androl 2008; 31(3): 303-14.
Hosseini J. Emadedin M. Mokhtarpour H. Sorani M. Prevalence of primary and sec- ondary infertility in four selected provinces in Iran, 2010-2011. Iran J Obstet Gynecol Infertil 2012; 15( 29): 1-7. [In Persian].
Che Y, Cleland J. Infertility in Shanghai: prevalence, treatment seeking and impact. J Obstet Gynaecol 2002; 22(6): 643-8.
Vayena E, Rowe PJ, Peterson HB. Assisted reproductive technology in developing coun- tries: why should we care? Fertil Steril 2002; 78(1): 13-5.
Oakley L, Doyle P, Maconochie N. Lifetime prevalence of infertility and infertility treat- ment in the UK: results from a population- based survey of reproduction. Hum Reprod 2008; 23(2): 447-50.
Himmel W, Ittner E, Kochen MM, Michel- mann HW, Hinney B, Reuter M, et al. Man- agement of involuntary childlessness. Br J Gen Pract 1997; 47(415): 111-8.
Buckett W, Bentick B. The epidemiology of infertility in a rural population. Acta Obstet Gynecol Scand 1997; 76(3): 233-7.
Bhattacharya S, Porter M, Amalraj E, Tem- pleton A, Hamilton M, Lee AJ, et al. The epidemiology of infertility in the North East of Scotland. Hum Reprod 2009; 24(12): 3096-107.
Adamson PC, Krupp K, Freeman AH, Klausner JD, Reingold AL, Madhivanan P. Prevalence & correlates of primary infertili- ty among young women in Mysore, India. Indian J Med Res 2011; 134: 440-6.
Imudia AN, Detti L, Puscheck EE, Yelian FD, Diamond MP. The prevalence of ureap- lasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorr- hoeae infections, and the rubella status of patients undergoing an initial infertility evaluation. J Assist Reprod Genet 2008; 25(1): 43-6.
Mares M, Socolov D, Doroftei B, Botezatu A, Goia CD. The prevalence of some bac- terial markers in female patients undergoing an initial infertility evaluation in north-east Romania. Roum Arch Microbiol Immunol 2009; 68(3): 171-4.
Neofytou E, Sourvinos G, Asmarianaki M, Spandidos DA, Makrigiannakis A. Preva- lence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. Fer- til Steril 2009; 91(6): 2487-94.
Gunnell DJ, Ewings P. Infertility preva- lence, needs assessment and purchasing. J Public Health Med 1994; 16(1): 29-3
| Files | ||
| Issue | Vol 1 No 1 (2014): Winter | |
| Section | Original Article(s) | |
| Keywords | ||
| Iran meta-analysi trend of infertility | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
